Project Grant R35GM161492
- Federal Project Grant Award Summary The Mount Desert Island Biological Laboratory (MDIBL) received a $432,543 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through July 31, 2030. The award funds the Emerging Leaders in Regenerative Biology and Development (REBILD) program, designed to address the critical workforce shortage in regenerative and developmental biology...
- Federal Grant Award Summary The Mount Desert Island Biological Laboratory received a $464,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 15, 2026, with completion targeted for January 31, 2031. The award funds fundamental research exploring tissue-specific mechanisms and requirements for nucleolin (NCL) organization in living organisms, with a focus on understanding...
- Federal Project Grant Award Summary The Marine Biological Laboratory (MBL) received a $471,625 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 15, 2026, through February 28, 2031. This award funds fundamental basic research investigating Wnt pathway activation mechanisms using sea star oocytes as a cellular model system. The research focuses on characterizing the...
- Federal Grant Award Summary The Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts, received a $471,625 Project Grant awarded August 1, 2025, through the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859). The award, with a completion date of May 31, 2030, funds fundamental research investigating the mechanisms controlling epithelial tube development, orientation, and integrity. The research employs the sea star...
- Federal Project Grant Award Summary The University of Southern California received a $351,920 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through August 31, 2030. This award supports fundamental research investigating the cellular and molecular determinants of regenerative capacity in amniotes, with a specific focus on understanding why certain lizard species...
- This federal Project Grant award for $169,000.00, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the development of a single-cell reference atlas of axolotl embryogenesis. The overarching goal is to elucidate the fundamental biological processes required for limb regeneration, with the aim of informing future regenerative medicine strategies for human limb injuries...
- Federal Project Grant Award Summary Cornell University's Office of Sponsored Programs received a $431,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, with a completion date of July 31, 2030. This research initiative focuses on enhancing understanding of intercellular communication to achieve programmable regeneration. The project will deliver fundamental...
- This $393,008 Project Grant, awarded March 1, 2026, by the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental research into the molecular mechanisms regulating cell fate specification during sensory organ regeneration. The University of California, Davis will conduct investigator-initiated research utilizing the freshwater apple snail (Pomacea canaliculata) as a model organism to elucidate how complex...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Integrative Organismal Systems awarded a Project Grant of $426,300 to The Marine Biological Laboratory (MBL) on July 15, 2025, under the Biological Sciences program (CFDA 47.074). The grant supports collaborative research investigating the development, evolution, and function of anterior lateral line systems in vertebrate fishes and amphibians through June 30, 2028. MBL will deliver specialized research services and...
- Federal Project Grant Award Summary The University of Maine received a $471,513 Project Grant award dated September 5, 2025, from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to conduct basic science research on tissue-specific roles for muscle-matrix adhesion in neuromuscular development and homeostasis. The research investigates the mechanisms underlying neuromuscular...
The Mount Desert Island Biological Laboratory received a $422,500 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026 through January 31, 2031. This award funds research into the molecular mechanisms of limb and tail regeneration in axolotls, with the ultimate goal of enabling development of novel strategies for scarless tissue regeneration in humans. The funded research will leverage advanced research tools and technologies—including transgenic axolotl generation, large-scale dataset analysis, and subcellular-resolution imaging—to elucidate the biological processes underlying successful regeneration in axolotls and to identify key differences between regenerative and non-regenerative species that could inform therapeutic approaches. The research program will advance fundamental understanding of how axolotls achieve complete limb and tail regeneration without fibrotic scarring through the formation of blastema progenitor cell pools. Building on prior discoveries regarding the critical role of fibroblast dedifferentiation in successful regeneration, the laboratory will continue investigating the molecular and cellular mechanisms that distinguish regenerative capacity in axolotls from the fibrosis observed in mammalian wound healing. The outcomes of this research are expected to provide foundational knowledge that could ultimately support the development of regenerative medicine approaches applicable to human tissue repair and regeneration.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $422.5k | 3/17/26 |