Project Grant R35GM161481
- The National Institute of General Medical Sciences awarded Duke University $474,507 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on cell signaling through O-linked glycosylation, with performance in Durham, North Carolina through March 31, 2031. The research focuses on O-linked β-N-acetylglucosamine (O-GlcNAc), a ubiquitous intracellular post-translational modification that decorates thousands of nuclear and cytoplasmic...
- The National Institute of Child Health and Human Development awarded Duke University $593,848 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop therapeutic approaches for glutaric aciduria type I (GA-1), an autosomal recessive metabolic disorder caused by deficiency of the enzyme glutaryl-CoA dehydrogenase (GCDH). The funded research builds on prior demonstration that murine GA-1 models can be rescued through liver-directed...
- The National Institute of General Medical Sciences awarded $439,281 to the University of California, San Diego on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and deliver GLYCOCRAFT.EDU, a modular, experiment-based educational platform for glycoscience training. The platform addresses underrepresentation of glycan research in biomedical education by providing portable, hands-on training kits that enable researchers at all career stages to...
- The National Institute of General Medical Sciences (NIGMS) awarded a $434,385 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Maine System, University of Maine Division. The grant, awarded on September 15, 2024, supports the development of a customizable 3D matrix to investigate the role of glycans in human health and disease. The research aims to enable the identification and characterization of glycan-protein interactions in a...
- The National Institute of General Medical Sciences awarded the University of New Mexico Health Sciences Center $419,375 on April 1, 2026, to investigate the systemic effects of metabolic enzyme dysfunctions under the Biomedical Research and Research Training program (CFDA 93.859). The recipient will conduct research examining how dysfunctions in D-2-hydroxyglutarate (2HG) metabolism cascade through interconnected biochemical pathways to produce systemic disease. 2HG is an intermediary in...
- The National Institute of General Medical Sciences awarded the Pacific Northwest Research Institute $1,231,446 in project grant funding on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the origin and functional impact of "hidden" structural variants in rare genetic diseases. The research examines DNA structural variants including inversions, complex genomic rearrangements, mobile element insertions, and balanced...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $211,433 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structural and biophysical principles governing protein-glycan interactions. The research program pursues three major objectives: defining the thermodynamic and structural basis of protein-glycan interactions at the atomic level to reveal how proteins achieve specificity within...
- The National Institute of General Medical Sciences awarded The Research Foundation for the State University of New York $343,007 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to characterize glycosylation regulatory networks using single-cell multiomics and mathematical modeling. The project generates single-cell epigenomics, transcriptomics, and glycomics profiles during hematopoietic stem cell differentiation to identify key regulators and...
- The National Institute of General Medical Sciences awarded the Carnegie Institution of Washington $335,000 on September 9, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how lamins regulate three-dimensional genome organization and gene expression during development. The project will characterize the mechanisms by which lamin proteins control nuclear lamina-associated domains and chromatin architecture in mouse embryonic stem cells and embryonic...
- The National Institute of General Medical Sciences awarded The Marine Biological Laboratory $471,625 on March 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate Wnt pathway activation and cell signaling using sea star oocytes as a model system. The research examines how Dishevelled (DVL), a protein essential to Wnt pathway integration, assembles into cytoplasmic structures upon hormonal stimulation of oocytes, and investigates oocyte-derived...
The National Institute of General Medical Sciences awarded Greenwood Genetic Center Inc. $284,847 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the intersection of glycosylation and metabolism during tissue development. The research employs zebrafish models to explore how metabolic and glycosylation pathways converge to control tissue development and how disruption of that coordination causes disease. The work focuses on congenital disorders of glycosylation (CDG), a group of rare inherited genetic diseases affecting approximately 200 different human conditions. Current studies include zebrafish models of multiple CDG subtypes, including PMM2-CDG, the most common form. The research combines systems-based analyses with biochemical and molecular approaches to characterize CDG pathogenesis at cellular and molecular levels. Performance takes place in Greenwood, South Carolina, with a period of performance extending from September 3, 2026 through June 30, 2031. The award is structured as a Project Grant, the standard assistance type for investigator-initiated biomedical research under NIGMS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $284.8k | 9/3/26 |