Project Grant R35GM156585

Award Date 6/15/25
Completion Date 5/31/30
Dollars Obligated $658K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Los Alamos, NM 87545, USA
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This federal Project Grant award, with a total funding amount of $658,165, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award aims to support research that focuses on understanding the fundamental mechanisms of ribosome function and mRNA regulation, with a specific emphasis on the role of ions and antibiotics. Key areas of investigation include:

  1. Elucidating the mechanisms by which initial codon sampling and tRNA selection occur in the ribosome, and how ions (including magnesium) impact these processes.
  2. Examining the effects of ions and antibiotics on ribosome function and mRNA regulatory elements (riboswitches).

The research leverages a combination of molecular simulations, time-resolved cryo-EM studies, and collaborations with experimental researchers. The grant was awarded on June 15, 2025, with a projected ultimate completion date of May 31, 2030. The principal investigator is conducting this work through Triad National Security, LLC, a for-profit limited liability company that manages and operates the Los Alamos National Laboratory.

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