The University of New Mexico Health Sciences Center (UNM HSC) has been awarded a $419,375 Project Grant under the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859). The 5-year grant, effective January 1, 2025, will fund research to define the functional dynamics of multidomain redox enzymes, with a focus on understanding the conformational control mechanisms and regulatory effects of interactions and modifications on the nitric oxide synthase (NOS) enzyme system. The research aims to provide unprecedented insights into how regulatory processes influence the conformational dynamics of multidomain proteins to fine-tune their biological activities, with potential applications in diverse areas of biology and medicine. The project will leverage UNM HSC's expertise in protein biophysics, structural biology, and mass spectrometry to develop novel integrative approaches for probing the complex dynamics of large, modular protein systems.
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