Intramuscular VS. Enteral penicillin prophylaxis to prevent progression of latent rheumatic heart disease: a non-inferiority randomized trial. (goalie)
Active Project Grant Awarded Last action
- Award ID
- R33HL166441
- Recipient
-
Childrens Hospital Medical Center UEI JZD1HLM2ZU83
- Awarding agency
-
National Heart Lung and Blood Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $15,040,098
Award facts
- Assistance listing
- 93.837 Cardiovascular Diseases Research
- Completion date 74% complete
- Place of performance
- Cincinnati, OH 45229, USA
Award details come from USAspending.gov.
Description
- Abstract
- Abstract rheumatic heart disease (RHD) remains a high prevalence condition in low-and-middle-income countries, currently affecting at least 40 million people, many of whom suffer premature death. Most patients with RHD present late, missing the opportunity to benefit from secondary antibiotic prophylaxis. Screening echocardiography in RHD endemic settings identifies many children with early, latent RHD, but until recently the effectiveness of prophylaxis to protect children with latent RHD was not known. The goal trial (conducted in uganda by this investigative team) found that children with latent RHD who receive prophylaxis with intramuscular penicillin are less likely to progress at two-years (0.8% penicillin VS. 8.3% no penicillin, P102,000 screened) and highly successful recruitment (>99% eligible children), retention (97% completion), and adherence support (99% adherence) strategies. The results of our study will have high clinical and public health impact, immediately informing international policy on the standard of care for children diagnosed with latent RHD.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $680,919 | |
| Amendment | $680,919 | |
| Amendment | $135,660 | |
| Amendment | $62,634 | |
| Amendment | -$680,919 | |
| Amendment | -$680,919 | |
| Amendment | $135,660 | |
| Amendment | $62,634 | |
| Amendment | -$62,634 | |
| Amendment | -$135,660 | |
| Amendment | -$135,660 | |
| Amendment | -$62,634 | |
| Amendment | $135,660 | |
| Amendment | $135,660 | |
| Amendment | $135,660 | |
| Amendment | $62,634 | |
| Amendment | $62,634 | |
| Amendment | $62,634 | |
| Amendment | $680,919 | |
| Amendment | $680,919 | |
| Amendment | $680,919 | |
| Amendment | $643,153 | |
| Amendment | $643,153 | |
| Amendment | $643,153 | |
| Amendment | $643,153 | |
| Amendment | $174,011 | |
| Amendment | $174,011 | |
| Amendment | $174,011 | |
| Amendment | $174,011 | |
| Amendment | $1,566,104 | |
| Amendment | $227,734 | |
| Amendment | $227,734 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $1,778,058 | |
| Amendment | $1,778,058 | |
| Amendment | $1,778,058 | |
| Original award | $1,778,058 |
Show all 40
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Murdoch Children's Research Institute | $135,660 | |
| University Of Melbourne | $62,634 | |
| Uganda Heart Institute | $680,919 | |
| Ochsner Clinic Foundation | $120,932 | |
| Uganda Heart Institute | $875,027 | |
| Children's Research Institute | $737,834 | |
| Murdoch Children's Research Institute | $190,709 | |
| University Of Washington | $363,509 | |
| Uganda Heart Institute | $210,214 |
Quick answers
Who received award R33HL166441?
R33HL166441 was awarded to Childrens Hospital Medical Center by National Heart Lung and Blood Institute (National Institutes of Health) on February 1, 2023.
How much is award R33HL166441 worth?
$15,040,098 has been obligated on R33HL166441.
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