Mhealth tympanometer: a digital innovation to address preventable childhood hearing loss in low- and middle-income countries

Ended Project Grant Awarded Last action

Award ID
R33DC020134
Recipient
Awarding agency
Obligated
$1,471,015

Award facts

Completion date
Place of performance
Little Rock, AR 72205, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Hearing loss is the second leading impairment worldwide. Childhood hearing loss has lifelong implications and disproportionately affects individuals in low- and middle-income countries (lmics). Up to 75% of childhood hearing loss in lmics is preventable due to the high prevalence of infection-related hearing loss. School hearing screening is critical for identification of childhood hearing loss in low resource settings, where newborn screening is unavailable. However, most screening programs only use pure-tone screening that does not identify middle ear disease widespread in populations with a high prevalence of infection-related hearing loss. This is because tympanometry, used to clinically identify middle ear disease, is expensive and designed for trained professionals. Our goal is to develop and validate an mhealth tympanometer with machine learning diagnostic support to transform this technology into a low-cost tool that could be broadly disseminated in lmics, where the burden of hearing loss is greatest and is not addressed by current hearing screening methodology. Our study team is comprised of international leaders in hearing loss, audiology, data science, engineering, user- centered design, and device development in lmics. We have also partnered with hearx, a university of pretoria spinout company that developed the only validated mhealth pure-tone screening device. To test this new device in an appropriate lmic setting, we have partnered with the south african site from the global hear collaborative, our consortium of collaborators from 28 countries that is the only international research network dedicated to hearing loss. We documented the need for this device in a large cluster randomized trial recently completed in rural alaska, where tympanometry significantly improved the accuracy of school hearing screening in a population with a high prevalence of infection-related hearing loss. Using data from this trial and pilot funding, we are developing a machine learning tympanometry algorithm for lay screeners, and early hardware prototype fabrication is underway. In aim 1, we will refine the hardware prototype using a user-centered design approach, cyclically incorporating feedback from south african team members during testing in a lab environment. In aim 2, we will develop software through user-centered design that integrates the machine learning algorithm and refined hardware prototype. The resulting mhealth tympanometer will advance to the R33 phase. Technology development will be completed in aims 3 and 4 through integration of the mhealth tympanometer with existing health information technology and an early feasibility study in 15 preschool children in south africa to optimize device design for lay users. In aim 5, we will validate the mhealth tympanometer with lay screeners through a clinical performance study in 500 preschool children in south africa. This technology, developed through partnership and testing in an lmic setting, will empower teachers and community health workers to identify children at risk for preventable hearing loss. The global hear collaborative will provide infrastructure for future studies with the proposed device across lmics, directly addressing disparities in childhood hearing loss globally.

Transactions

Action Obligated Date
Amendment $21,088
Amendment $5,000
Amendment $286,316
Amendment $37,076
Amendment $37,076
Amendment $5,000
Amendment -$5,000
Amendment -$5,000
Amendment $272,365
Amendment $272,365
Amendment $272,365
Original award $272,365
Show all 12

Subawards

Subrecipient Amount Awarded
University Of Pretoria mHealth Tympanometer: A Digital Innovation to Address Preventable Childhood Hearing Loss in Low- and Middle-Income Countries $21,088
Duke University $35,571
University Of Pretoria $0
University Of Pretoria $39,756
Duke University $35,665
Duke University $70,111
University Of Pretoria mHealth Tympanometer: a Digital Innovation to Address Preventable Childhood Hearing Loss in Low and Middle Income Countries $78,702
Duke University $34,760
University Of Pretoria $56,973
Duke University $65,046
Duke University mHealth Tympanometer: A Digital Innovation to Address Preventable Childhood Hearing Loss in Low- and Middle-Income Countries $43,992
University Of Pretoria $22,062
University Of Pretoria $30,665
Duke University $26,914
Show all 14

Quick answers

Who received award R33DC020134?

R33DC020134 was awarded to University Of Arkansas For Medical Sciences by National Institute on Deafness and Other Communincation Disorders (National Institutes of Health) on May 15, 2022.

How much is award R33DC020134 worth?

$1,471,015 has been obligated on R33DC020134.

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