Enhancing the calerie network to advance aging biology abstract: in direct response to PA-20-071, advanced-stage development and utilization of research infrastructure for interdisciplinary aging…
Ended Project Grant Awarded Last action
- Award ID
- R33AG070455
- Recipient
-
Duke University UEI TP7EK8DZV6N5
- Awarding agency
-
National Institute on Aging
National Institutes of Health, Department of Health and Human Services
- Obligated
- $14,408,486
Award facts
- Assistance listing
- 93.866 Aging Research
- Completion date
- Originally
- Funding
-
- $13,685,245.00 Federal
- $723,241.00 Non-federal
- Place of performance
- North Carolina, USA
Award details come from USAspending.gov.
Description
Enhancing the calerie network to advance aging biology abstract: in direct response to PA-20-071, advanced-stage development and utilization of research infrastructure for interdisciplinary aging studies), we propose to enhance and grow the calerie research network into a self- sustaining infra-structure of samples, data, and aging biology investigators. The comprehensive assessment of long-term effects of reducing intake of energy (calerie) was a randomized controlled trial designed to assess the effects in humans of two years of sustained caloric restriction without enforced changes of dietary composition. The overall objective was to elucidate underlying biological mechanisms and mediators of primary and secondary human aging. The rigorous design and execution of the calerie intervention produced an invaluable resource, including comprehensive phenotypic data that are coupled to biological samples. To ensure continued use of these samples and data, we describe a plan to create a self-sustained calerie network. Our aims are to advance aging research through enhanced 1) utilization, 2) development and interdisciplinary growth of the calerie research network. Utilization of calerie resources will be promoted and stewarded by a steering committee, an NIA biobank representative, NIA-supported networks and centers, annual workshops and working groups. These efforts will ensure best use of remaining calerie samples as well as incorporation of new data into a complex multi-level database. Calerie network inter- disciplinary growth will be fostered by attracting new and junior aging biologists to pilot projects, career development activities, and a rich pipeline of integrative systems biology projects. By developing more investigators, projects, and disciplines, new data and samples will be generated and will perpetuate the aging biology scientific cycle. Thus, completion of these aims should yield a mature, sustainable infrastructure that maintains and oversees calerie samples and data, perpetuates calerie ancillary integrative investigations, and contributes to overall advancement of understanding of human aging biology.
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $0 | $0 | |
| Amendment | $642,802 | $0 | |
| Amendment | $642,802 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $50,380 | $0 | |
| Amendment | $50,380 | $0 | |
| Amendment | $50,380 | $0 | |
| Amendment | $50,380 | $0 | |
| Amendment | $50,380 | $0 | |
| Amendment | $566,788 | $0 | |
| Amendment | $566,788 | $0 | |
| Amendment | $566,788 | $0 | |
| Amendment | $566,788 | $0 | |
| Amendment | $566,788 | $0 | |
| Amendment | $566,788 | $0 | |
| Amendment | $63,632 | $0 | |
| Amendment | $63,632 | $0 | |
| Amendment | $63,632 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $572,692 | $0 | |
| Amendment | $572,692 | $0 | |
| Amendment | $572,692 | $0 | |
| Amendment | $572,692 | $0 | |
| Amendment | $572,692 | $0 | |
| Amendment | $642,884 | $0 | |
| Amendment | $642,884 | $0 | |
| Amendment | $642,884 | $0 | |
| Amendment | $642,884 | $0 | |
| Amendment | $93,206 | $0 | |
| Amendment | $93,206 | $0 | |
| Amendment | $93,206 | $0 | |
| Amendment | $66,431 | $0 | |
| Amendment | $66,431 | $0 | |
| Amendment | $66,431 | $0 | |
| Amendment | $597,864 | $0 | |
| Amendment | $597,864 | $0 | |
| Amendment | $723,241 | $0 | |
| Original award | $723,241 | $723,241 |
Show all 47
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Pennington Biomedical Research Center | $37,917 | |
| The Trustees Of Columbia University In The City Of New York | $164,500 | |
| Arizona State University | $25,117 | |
| Trustees Of Tufts College | $24,763 | |
| Regents Of The University Of Minnesota | $50,820 | |
| Arizona State University | $127,267 | |
| Pennington Biomedical Research Center | $435,285 | |
| Trustees Of Tufts College | $168,285 | |
| Adventist Health System / Sunbelt Inc. | $29,878 | |
| Trustees Of Tufts College | $27,524 | |
| The Rochester General Hospital | $248,555 | |
| The Washington University | $55,694 |
Show all 12
Quick answers
Who received award R33AG070455?
R33AG070455 was awarded to Duke University by National Institute on Aging (National Institutes of Health) on February 15, 2021.
How much is award R33AG070455 worth?
$14,408,486 has been obligated on R33AG070455: $13,685,245 in federal funding and $723,241 in non-federal funding.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award