A genomic toolkit for functional interrogation of trait variation in an aquatic model

Active Project Grant Awarded Last action

Award ID
R24OD030214
Recipient
Awarding agency
Obligated
$6,389,164

Award facts

Assistance listing
93.351 Research Infrastructure Programs
Completion date 95% complete
Originally
Funding
  • $6,323,579.00 Federal
  • $65,585.00 Non-federal
Funding agency
Office of the Director National Institutes of Health, Department of Health and Human Services
Place of performance
Columbia, MO 65211, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
In the study of disease, the polygenic factors that lead to genetic adaptation in species, essentially who will be asymptomatic while under environmental stressors, mostly remain undiscovered. Without a comparative understanding of these unique features by cell type, that evolution has preserved, our efforts to more broadly implement precision medicine will be limited in multiple phenotypes. One of the most promising applications of evolutionary medicine has been the use of divergent animal models to deconstruct and uncover fundamental concepts of biological organization in great detail. The mexican cavefish, astyanax mexicanus provides a rapidly growing model system to apply principles of evolutionary medicine to study trait variation. We have implemented a toolbox of genetic tools that allow for functional interrogation of various traits in the mexican cavefish, but key resources are missing. This model species consists of surface and cavefish populations that possess natural trait differentiation, often displaying genetic adaption associated with environmental change, without impacting health or longevity. The objectives of our studies are to generate three tiers of community requested resources: high-quality surface and cavefish genome assemblies, using powerful single-cell sequencing technology a cell atlas with differentiating gene expression data sets and targeted gene reporter constructs coupled with a spatial understanding of their gene regulatory effects. This compendium of resource data and methodology can serve a large community wishing to test various hypotheses of adaptation in this species and others. Our proposed research objectives are significant in that they will contribute comparative gene networks that reveal novel differences with a growing assemblage of gene candidates for human diseases.

Transactions

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Original award $611,488 $0
Show all 15

Subawards

Subrecipient Amount Awarded
Universitat Munster A genomic toolkit for functional interrogation of trait variation in an aquatic model $50,000
Texas A & M University Develop genomic and genetic tools for examining brain function in cavefish. It includes a new annotation of the cavefish genome, defining brain function in… $168,906
Stowers Institute For Medical Research Fish in caves have evolved a suite of human relevant phenotypes as part of their adaptation to nutrient limited and dark environments. We have previously… $80,574
Texas A & M University Develop genomic and genetic tools for examining brain function in cavefish. It includes a new annotation of the cavefish genome, defining brain function in… $143,653

Quick answers

Who received award R24OD030214?

R24OD030214 was awarded to University Of Missouri System by Aggregate Financial Assistance Data (National Institutes of Health) on March 15, 2022.

How much is award R24OD030214 worth?

$6,389,164 has been obligated on R24OD030214: $6,323,579 in federal funding and $65,585 in non-federal funding.

Which agency awarded R24OD030214?

Aggregate Financial Assistance Data (National Institutes of Health) awarded R24OD030214, with funding from Office of the Director (National Institutes of Health).

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