Project Grant R21OD018317

This Project Grant award from the National Institutes of Health's (NIH) Research Infrastructure Programs (CFDA 93.351) provides $775,888 to the La Jolla Institute for Immunology to develop and validate a novel CRISPR-ready, HLA transgenic mouse platform. The platform will enable researchers to rapidly generate mice expressing specific HLA class I and II alleles relevant to a broad range of diseases, including infection, cancer, autoimmunity, and transplant rejection. This versatile platform will...

This $881,450 Project Grant, awarded by the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351), will fund the development of novel humanized mouse models to support the study of human tissue-resident macrophages and their role in human diseases. The key objectives are: Generating genetically-modified NSG mouse strains that are deficient in mouse tissue-resident macrophages and express human cytokines to promote human myeloid cell...

This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $844,954 to New York University School of Medicine to develop "Genomically Rewritten and Tailored Humanized Mouse Models for Various Organ Disorders". The award leverages advanced DNA synthesis and genome editing technologies to create mouse models that accurately recapitulate human disease phenotypes. These "GREAT-GEMMS" (Genomically...

This three-year, $8.29 million project grant from the National Institutes of Health National Institute on Aging will support the development of full human gene replacement mouse models of Alzheimer's disease. Funded under the Aging Research program (CFDA 93.866), the Regents of the University of Minnesota will generate mouse lines with replacement of key Alzheimer's-related genes, including APP, PSEN1, PSEN2, MAPT, APOE, TREM2, MS4A, and INPP5D, with their full human orthologues. Control lines...

This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) will provide $240,750 to support the development, validation, and broad dissemination of a new mouse model for targeting mature brown adipocytes. The award will be utilized by the Children's Hospital Medical Center in Cincinnati, Ohio to generate this novel CRISPR/Cas9-engineered mouse model with a Cre-recombinase driver under the UCP1 promoter. The project aims to...

This Project Grant award from the National Institutes of Health (NIH), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,035,691 to Wake Forest University Health Sciences (WFUHS) to develop novel mouse models of hepatitis B virus (HBV) infection and replication. The goal is to create robust mouse models to investigate HBV infection, transcription, replication, pathogenesis, and host immune response, as well as to evaluate HBV-specific antiviral drugs and...

This Project Grant award under the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of prototype mouse models to investigate the SEND (Selective Endogenous Encapsidation for Cellular Delivery) system for mRNA delivery and gene therapy applications. The $330,025 award, provided by the Department of Health and Human Services (HHS), will fund the creation of three genetically engineered mouse models to...

This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $240,039 to Baylor College of Medicine to develop a novel mouse model for detecting genome editing events. The project aims to create a more sensitive reporter system using CRISPR/Cas9 technology, where editing of a specific genetic domain triggers the expression of a fluorescent marker protein. This would allow for improved monitoring of genome editing events...

This $143,800 Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) supports the development of mouse models for targeted manipulation of DNA methylation at specific genomic loci. The goal is to create simple, robust tools for epigenetic gene targeting that can advance functional studies of DNA methylation and its role in human health and disease. Specifically, the awardee, Baylor College of Medicine, will develop two mouse...

This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) will fund Cornell University to develop and test two novel mouse models that enable greater in vivo experimental control and cellular-level analysis for studying complex human diseases. The first model is a "Unilateral Mosaic" that restricts disease-driving gene expression to one side of an organ, like the lung, creating an internal disease-prone and...