Project Grant R21NS142788
- Federal Grant Award Summary The Defense Health Agency (DHA) awarded Translational Genomics Research Institute (TGen) a $192,000 project grant effective September 1, 2025, through August 31, 2027, under the Military Medical Research and Development program (CFDA 12.420). Titled "Single: Signature Enabling Glioma Enrollment," this award supports research activities focused on glioma investigation and patient enrollment strategies. As a non-profit research organization specializing in...
- Federal Project Grant Award Summary The Defense Health Agency (DHA) awarded Translational Genomics Research Institute (TGen) a $384,000 project grant effective September 1, 2025, through August 31, 2027, under the Military Medical Research and Development program (CFDA 12.420). The project, titled "Single: Signature Enabling Glioma Enrollment," supports research and development activities focused on glioma-related medical challenges. Based on TGen's established expertise in precision...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Translational Genomics Research Institute (TGen) a Project Grant totaling $543,351 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, through July 31, 2027. The research initiative focuses on developing and characterizing a novel transgenic mouse model engineered to elucidate the disease mechanisms...
- Federal Project Grant Award Summary Georgetown University received a $429,000 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded April 16, 2026, with completion targeted for March 31, 2028. The award funds research investigating epigenetic biomarkers in glioblastoma (GBM), the most common malignant primary brain tumor in adults. Specifically,...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The University of Texas Southwestern Medical Center a Project Grant totaling $656,879 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 1, 2025, through July 31, 2030. This award supports research investigating the mechanisms of glioma initiation driven by isocitrate dehydrogenase (IDH) oncogenes. The research...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant totaling $429,000 to the University of Michigan's Office of Research and Sponsored Projects, effective August 1, 2025, through July 31, 2027, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research project investigates the mechanism of Notch inhibition resistance in glioblastoma (GBM) stem cells to develop novel...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $188,566 Project Grant to the University of Texas Health Science Center at Houston on July 3, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award supports a two-year research initiative (through September 3, 2027) investigating the role of Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) on microglia and...
- Federal Project Grant Award Summary Baylor College of Medicine received a $624,825 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective March 15, 2026, with an ultimate completion date of February 28, 2031. The grant funds the development of computational methods to characterize the electrophysiological and genomic profiles of gliomas,...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Columbia University's Health Sciences Division a $610,554 Project Grant effective August 1, 2025, through July 31, 2030, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative investigates the mechanistic relationship between mammalian target of rapamycin (mTOR) and gamma-aminobutyric acid (GABA)ergic...
- Federal Grant Award Summary The Broad Institute of MIT and Harvard received a $404,282 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded on May 1, 2026, with completion scheduled for April 30, 2028. The research focuses on engineering transferrin receptor 1 (TFR1)-binding adeno-associated virus (AAV) capsids capable of evading pre-existing...
The Translational Genomics Research Institute (TGen) received a $305,960 Project Grant award dated April 15, 2026, from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research on glioma cell dissemination and tumor-microenvironment interactions through spatial transcriptomics analysis and computational modeling. The research will deliver spatial transcriptomics data from 254 image-mapped samples across 22 distinct tumors, characterizing diffuse infiltration patterns of neural progenitor cell-like, oligodendrocyte progenitor cell-like, and astrocyte progenitor cell-like tumor populations within brain tissue. Additionally, the project will produce an agent-based computational model integrating imaging, DNA methylation, and DNA sequencing data from 179 samples across 20 patients to reconstruct historical and forecast future glioma cell dissemination patterns in four-dimensional space and time. These deliverables are intended to enable high-resolution identification of ancestral stem-like tumor cell populations and sites of diffuse infiltration, ultimately supporting individualized local treatment planning and prognostication for glioma patients. The award period extends through March 31, 2028.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $306.0k | 4/13/26 |