This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA Program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to investigate methods for converting scar-forming fibroblast cells into neurons after spinal cord injury. The goal is to restore lost neurons and repair neural circuits without cell transplantation. The $451,000 award to the University of Texas Southwestern Medical Center will fund research...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $151,559 to Rensselaer Polytechnic Institute (RPI) from August 3, 2024 to July 31, 2026. The project aims to develop innovative magnetically responsive drug delivery electrospun fibers to improve regeneration after spinal cord injury (SCI). Specifically, the research will focus...
This federal Project Grant award of $458,154, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research conducted by Microcures Inc. to develop a nanoparticle-encapsulated siRNA formulation that targets the Fidgetin-like 2 (FL2) protein to promote tissue repair and functional recovery after spinal cord injury. The goal is to demonstrate the...
This $391,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to develop effective therapeutic strategies for spinal cord injury (SCI) by evaluating controlled PTEN deletion and chondroitin sulfate proteoglycans (CSPGs) degradation to promote axon regeneration and functional recovery. The key objectives are to: 1) Temporally evaluate...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), provides $591,304 to the University of Louisville to investigate the role of the integrated stress response (ISR) pathway, specifically the ISR kinase HRI, in the secondary injury and neuroinflammation following traumatic spinal cord injury (SCI). The research aims to define the cell-specific...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $469,898 to Yale University to conduct research on mechanisms supporting raphespinal tract plasticity and regeneration after spinal cord injury. The research aims to use anatomy, spatial transcriptomics, and intersectional in vivo chemogenetics to define the capacity and...
This $424,875.00 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund a comprehensive study of gene transcription patterns in diverse classes of neurons that connect the brain to the spinal cord after spinal cord injury in a mouse model. The research team at Marquette University will use single-cell sequencing technologies to profile...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,735,024.00 to Wayne State University to develop a non-invasive infrared light therapy and medical device to treat spinal cord injury (SCI). The award aims to attenuate the acute injury and inflammatory response in the initial early phase following SCI, which can lead to neuronal...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $462,296 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of Louisville to conduct research on propriospinal plasticity and recovery after incomplete spinal cord injury. The project aims to investigate the anatomical plasticity exhibited by long-ascending propriospinal neurons (LAPNs) following spinal cord injury, the impact of silencing...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will provide $545,612 to The Ohio State University to conduct research aimed at reducing adipose tissue dysfunction and metabolic complications after spinal cord injury (SCI). The key objectives are to evaluate the extent to which modulating the A2D1 subunit of voltage-gated...