Project Grant R21MH141189
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $734,707 on August 13, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the coordinated maturation of neurons and synapses in the adolescent human neocortex. The research develops a pipeline to retrieve and analyze tissue specimens resected during pediatric neurosurgical procedures for epilepsy, vascular malformations, or brain tumors. The study examines whether postnatal...
- The National Institute of Mental Health awarded Cold Spring Harbor Laboratory $528,000 on June 19, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support developmental characterization of synapses between neurons and oligodendrocyte precursor cells. The funded research investigates structural, functional, and molecular properties of neuron-OPC synapses, a class of synaptic connections that remain poorly understood despite evidence that oligodendrocyte precursor cells...
- The National Institute of Mental Health awarded $452,386 to President and Fellows of Harvard College on September 1, 2026, to study the plasticity of synaptic cotransmission in the mouse lateral habenula under the Mental Health Research Grants program (CFDA 93.242). The research investigates how changes in the valence of learned associations induce synaptic plasticity in the lateral habenula—a brain structure implicated in mood disorders—and subsequently alter downstream dopamine signaling....
- The National Institute of Mental Health awarded Cold Spring Harbor Laboratory $897,709 under the Mental Health Research Grants program (CFDA 93.242) on September 1, 2026, for investigation of the molecular mechanisms underlying assembly of axo-axonic synapses in the cerebral cortex. The project focuses on synaptic connectivity between excitatory pyramidal neurons and inhibitory GABAergic interneurons, specifically chandelier cells (axo-axonic cells). Chandelier cells form synapses exclusively at...
- The National Institute of Mental Health awarded Scripps Research Institute $878,601 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support structural remodeling of neural circuits via multisynaptic boutons. The research uses three-dimensional electron microscopy at nanometer resolution to reconstruct neuronal connectomes, individual synapses, and glia in the mammalian brain. The work combines 3D-EM with chemogenetic techniques for labeling cellular ensembles...
- The National Institute of Mental Health awarded The McLean Hospital Corporation $179,096 on June 18, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neurocognitive mechanisms underlying negative retrieval bias in major depressive disorder. The recipient will conduct research to distinguish between two competing mechanisms that may explain how depression disrupts emotional memory: increased familiarity (depression strengthens evidence for all negative...
- The National Institute of Mental Health awarded The Research Foundation For The State University Of New York $802,543 on June 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to dissect the role of astrocytes in mediating adverse outcomes of maternal immune activation. The project grant funds research examining how prenatal infections triggering maternal immune activation contribute to neurodevelopmental disorders including schizophrenia, autism spectrum disorder, and...
- The National Institute of Mental Health awarded $182,916 to Trustees of Tufts College, doing business as Tufts University School of Medicine, on October 17, 2025, under the Mental Health Research Grants program (CFDA 93.242) to conduct research evaluating cell type-specific mechanisms of glutamatergic synapse function and organization in interneurons. The research uses molecular biology, proteomic analysis, live cellular imaging, and electrophysiology to investigate how the protein BTBD11...
- The National Institute of Mental Health awarded Massachusetts Eye and Ear Infirmary $666,010 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study co-transmission of GABA and glutamate in cortical circuits and the role of neuromodulatory inputs in adult cortical plasticity. The recipient will employ anatomical circuit tracing, whole-cell electrophysiology, and in vivo two-photon imaging in mouse cortex to investigate how cholinergic and serotonergic...
The National Institute of Mental Health awarded The McLean Hospital Corporation $463,229 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate synaptic function programs in neuron-astrocyte co-cultures derived from human post-mortem brain tissue. The award funds research combining primary human astrocyte cultures and induced pluripotent stem cell-derived astrocytes and neurons isolated from the same human post-mortem brain donor tissue. The research examines coordinated gene expression programs—termed synaptic neuron astrocyte programs (SNAP)—that support synaptic functions through multicellular interactions between neurons and glial cells. The work addresses synaptic pathology as a convergence point across psychiatric, neurodevelopmental, and neurodegenerative disorders, with SNAP enriched in schizophrenia risk variants and reduced in schizophrenia and aging. Primary astrocytes are isolated from the frontal lobe, while dura mater-derived fibroblasts from the same donor are reprogrammed into induced pluripotent stem cells and differentiated into astrocytes and neurons to enable study of cell interactions within the same individual. The period of performance runs from September 1, 2026, through August 31, 2028. Work is performed in Belmont, Massachusetts. This is a Project Grant, a non-renewable assistance type under the Mental Health Research Grants program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $463.2k | 8/28/26 |