Epigenetic biomarkers of postpartum psychosis

Ended Project Grant Awarded Last action

Award ID
R21MH134114
Recipient
Awarding agency
Obligated
$898,000

Award facts

Assistance listing
93.242 Mental Health Research Grants
Completion date
Place of performance
Virginia, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Reproductive mood episodes, such as postpartum depression, premenstrual dysphoric disorder and postpartum psychosis, are mood episodes triggered by reproductive hormonal changes in women. We have previously identified two epigenetic biomarkers of postpartum depression at the TTC9B and HP1BP3 genes that are approximately 80% accurate in predicting which women will be depressed in the postpartum time- period. We have recently shown that these biomarkers are also associated with women that have premenstrual dysphoric disorder when blood is sampled in the luteal phase of the menstrual cycle indicating that they may be more general biomarkers of brain sensitivity to reproductive hormone fluctuations. This proposal will take advantage of a unique sample of blood specimens collected in the netherlands from women with postpartum psychosis and will determine if our epigenetic biomarkers are also associated with postpartum psychosis. We will also conduct a genome wide microarray analyses in order to identify epigenetic biomarkers that are specific to postpartum psychosis. Postpartum psychosis is a serious psychiatric illness with acute onset in the immediate postpartum time period. Postpartum psychosis almost always requires psychiatric hospitalization and carries with IT an elevated risk of suicide and infanticide. Identification of blood-based biomarkers that are predictive of an increased risk for postpartum psychosis would allow for preventative measures which may eliminate a psychiatric emergency and prevent hospitalization during the critical postpartum time period.

Transactions

Action Obligated Date
Amendment -$4,276
Amendment $0
Amendment $451,138
Original award $451,138

Subawards

Subrecipient Amount Awarded
University Of Ottawa Institute Of Mental Health Research During the course of this project, Dr. Kaminsky, upon receipt of the data, will preprocess and analyze the data according to the aims of the grant. Dr. Kaminsky… $26,040
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC) We plan to work together to determine if previously identified biomarkers are present in women who developed PPP and to look for other epigenetic biomarkers… $11,861
Icahn School Of Medicine At Mount Sinai The Icahn School of Medicine at Mount Sinai (ISMMS) team will participate actively in the scientific aims of this proposal under the direction of Dr. Jennifer… $39,242
University Of Ottawa Institute Of Mental Health Research During the course of this project, Dr. Kaminsky, upon receipt of the data, will preprocess and analyze the data according to the aims of the grant. Dr. Kaminsky… $26,036
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC) Statement of Work Title: Epigenetic Biomarkers of Postpartum Psychosis Background information: Postpartum Psychosis (PPP) is a serious psychiatric illness… $22,054
Icahn School Of Medicine At Mount Sinai The Icahn School of Medicine at Mount Sinai (ISMMS) team will participate actively in the scientific aims of this proposal under the direction of Dr. Jennifer… $39,242

Quick answers

Who received award R21MH134114?

R21MH134114 was awarded to Rector & Visitors Of The University Of Virginia by National Institute of Mental Health (National Institutes of Health) on August 2, 2023.

How much is award R21MH134114 worth?

$898,000 has been obligated on R21MH134114.

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