This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $743,852 to Saint Louis University (SLU) to acquire an XTALAB SYNERGY-R single crystal diffractometer. This state-of-the-art scientific instrument will enable researchers across 13 different SLU colleges, as well as collaborators from Southern Illinois University Edwardsville, to collect high-quality X-ray diffraction data from organic compounds and biological macromolecules. The...
This Project Grant from the National Science Foundation's Integrative Activities program totaling $154,755 will enhance structural science capacity in the Rocky Mountain Northwest region through microcrystal electron diffraction training. The University of Montana will provide comprehensive microcrystal electron diffraction analysis instruction and experience to the principal investigator and two trainees from remote learning and collaborative visits to the National Center for Cryo-Electron...
This $165,123 project grant from the National Science Foundation's Mathematical and Physical Sciences program will support the development of new computational methods and software tools for predicting polymorphic crystal structures of organic molecules and elucidating phase transition mechanisms. Mark Tuckerman of New York University and Jerome Delhommelle of the University of North Dakota will create a topological theory for crystal structure generation based solely on molecular order...
The National Science Foundation awarded a $300,735 Project Grant to Harvard University under the Mathematical and Physical Sciences program (CFDA 47.049) to acquire a dual-source single crystal diffractometer for small molecule crystallography and cryosystem. The diffractometer will allow Professor Theodore Betley and colleagues to conduct accurate structural analyses of molecules, providing three-dimensional atomic arrangements and spatial relationships between molecules and neighboring...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $1,204,713 in funding to support the DIALS diffraction data processing package, a mature software product used worldwide for X-ray crystallography data analysis. The award will establish DIALS as a U.S. national resource, shifting funding from primarily research grants to a combination of research and operational support. This...
The National Science Foundation (NSF) Office of Integrative Activities awarded Susquehanna University a $200,170 Project Grant under the Integrative Activities program (CFDA 47.083) to acquire a single-crystal X-ray diffractometer. This instrument will support primarily undergraduate research in the greater Susquehanna Valley region, including efforts at Susquehanna University, Bucknell University, Lycoming College, Elizabethtown College, and Wilkes University. The diffractometer, which has a...
The New York Structural Biology Center, Inc. has been awarded a $1,995,724 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to acquire a state-of-the-art 800 MHz NMR spectrometer console and associated probes. This instrumentation will enhance the capacity of the existing 800 MHz NMR system to support a range of NIH-funded structural biology research, from fundamental studies of biomolecular...
This National Science Foundation Project Grant award of $1,245,633 provides funding to Cornell University from October 1, 2022 through September 30, 2026 to develop new instrumentation and methods for millisecond time-resolved studies of protein dynamics using quenching crystallography. The goal is to deliver a solution enabling time-resolved studies of protein structural changes with millisecond resolution in any laboratory setting. Funding is provided through the Biological Sciences program...
Purdue University was awarded a $399,459 project grant from the National Science Foundation's (NSF) Computer and Information Science and Engineering program to develop computational methods for the systematic identification of unknown biomolecular structures from cryo-electron tomography images. Over a three-year period ending in September 2025, the university will create an automated computational pipeline integrating novel techniques for fast subtomogram alignment, shape searching against...
The National Science Foundation awarded the University of Notre Dame a $287,021 Project Grant under the Integrative Activities federal grant program (CFDA 47.083) to acquire a dual-source single-crystal x-ray diffractometer. The diffractometer will be used to determine the precise three-dimensional molecular structures of organic and inorganic compounds, metal complexes, solid-state materials and other substances. This will support the research of Professor Allen Oliver and colleagues in areas...