Project Grant R21ES038727
- Federal Project Grant Award Summary Central Michigan University received a $304,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on March 15, 2026, with completion targeted for February 28, 2031. The award funds a five-year research initiative investigating how social stress and androgenic signaling regulate oxidative stress in the brain, with research to be conducted at the...
- Federal Project Grant Award Summary Boston University Medical Campus received a $147,486 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded November 1, 2025, with completion targeted for August 31, 2028. This research project will investigate the neurodevelopmental impacts of early-life exposure to ferroalloy metal mixtures—including manganese, lead, chromium, and copper—on adolescent cognitive...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded $163,614 to the University of Illinois, effective September 1, 2025, through March 31, 2029, under the Environmental Health program (CFDA 93.113). This research project investigates lipid-based interventions to mitigate arsenic-induced neurobehavioral dysfunction through a complementary approach combining in vivo mouse studies and ex vitro microglial experiments. The research seeks to...
- Federal Project Grant Award Summary The University of Michigan received a $3.13 million Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded September 10, 2025, with completion targeted for September 9, 2029. This research initiative will integrate exposome and epigenome data to identify determinants of amyotrophic lateral sclerosis (ALS) risk, survival, and pathogenesis. The project comprehensively...
- Federal Grant Award Summary Materials Nova Limited Liability Company received a $314,745 Project Grant from the National Institute of Environmental Health Sciences under the Environmental Health program (CFDA 93.113), awarded September 17, 2025, with completion targeted for August 31, 2027. The award supports the development of an ultra-sensitive, rapid, point-of-use (POU) mercury sensor designed to detect toxic mercury contamination in freshwater sources. The deliverable is a portable,...
- Federal Grant Award Summary Michigan State University received a $100,000 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded September 27, 2025, with completion targeted for August 31, 2027. The award supports research investigating the role of the epicardium and inositol-requiring enzyme 1A (IRE1A) in mediating environmental chemical exposures on cardiac function. The project utilizes human heart...
- Federal Project Grant Award Summary Michigan State University's Health Sciences partnership (in collaboration with Henry Ford Health) received a $1.58M Project Grant from the National Institute of Environmental Health Sciences (NIEHS) Environmental Health program (CFDA 93.113), awarded April 1, 2026, with completion targeted for January 31, 2031. The research investigates the epigenetic control mechanisms of high-confidence autism spectrum disorder (ASD) genes, with particular emphasis on the...
- Federal Project Grant Award Summary The University of Rochester received a $415,613 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded February 24, 2026, with completion targeted for January 31, 2028. The funded research investigates how pregnancy influences methylmercury (MeHg) metabolism and elimination in pregnant women and their developing fetuses. The project builds upon preliminary evidence...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded The Trustees of Columbia University in the City of New York a $942,408 Project Grant under the Environmental Health program (CFDA 93.113), effective June 1, 2026, through May 31, 2034. This eight-year research initiative, titled "Revolutionary Environmental Metalloproteomics for Aging Science and Prevention," develops advanced biomarkers and analytical methodologies to assess...
- Federal Grant Award Summary The University of Michigan received a $3,977,894 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded August 1, 2025, with completion targeted for July 31, 2028. This grant funds development of a scalable high-plex pipeline for whole-brain proteomics profiling that addresses critical gaps in molecular characterization of distinct brain cell types. The project delivers a comprehensive...
Central Michigan University received a $394,165 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded June 11, 2026, with completion targeted for June 10, 2028. The grant supports research investigating the neural mechanisms by which methylmercury (MeHg) exposure disrupts frontal cortical circuits controlling emotion and cognition. The research employs an integrative neuroscience approach combining in vivo multiunit electrophysiological recordings in awake animals to assess effects on neural spiking activity patterns, synaptic transmission analysis in acute brain slices from chronically exposed animals, and molecular-level investigations of the medial prefrontal cortex (mPFC) and anterior insular cortex (AIC)—two brain regions critical to emotional and cognitive regulation. This research addresses a significant public health concern, as mercury is designated by the World Health Organization as one of the top 10 chemicals of major public health concern due to its global distribution and documented neurotoxic effects on cognition and mood. The proposed work bridges the gap between known acute effects of MeHg on synaptic function at the cellular level and poorly understood in vivo circuit-level consequences, thereby contributing foundational knowledge to support future intervention strategies and public health policy regarding this persistent environmental neurotoxicant.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $394.2k | 6/12/26 |