Project Grant R21ES037389
- This $463,375 federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) supports research at the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Tampa, Florida. The research aims to identify and characterize the role of melanin-carbonyl-DNA (MCD) and melanin-carbonyl-protein (MCP) adducts in the progression and treatment resistance of NRAS mutant melanoma. The key objectives are to...
- This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), supports research into how exposure to polychlorinated biphenyls (PCBs) and high-fat diets impact the development of metabolic dysfunction-associated steatotic liver disease (MASLD). The $3,051,769 award to the University of Louisville aims to determine how environmental exposures and diet modify RNA modifications, specifically...
- This $483,077 federal Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) supports research by Baylor College of Medicine to investigate the role of the estrogen-related receptor gamma (ESRRG) gene in regulating circadian rhythms and their influence on the progression from nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC). The 5-year project aims to elucidate how ESRRG, as a noncanonical circadian clock...
- This $380,089.00 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental research on the molecular mechanisms underlying circadian rhythms. The project aims to determine the mechanisms that define the period and light-dependent phase shift of circadian rhythms, which are critical for aligning cellular and physiological processes with external environments. By...
- This Project Grant award, funded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program, supports research investigating the effects of ultraviolet radiation (UVR) exposure on chromatin structure and gene expression in melanocytes, which are the origin of cutaneous malignant melanoma. The $156,250 award, granted to the University of Toledo Health Science Campus, aims to elucidate how the loss of the BRG1 chromatin remodeling...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $451,250.00 to Children's Hospital Medical Center in Cincinnati, Ohio to investigate the molecular basis of circadian and sensory integration in neuronal clocks. The research aims to understand how gene expression in brain oscillators is affected when clock gene rhythms are disrupted in the suprachiasmatic nucleus,...
- This $574,021 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to advance the scientific understanding of the molecular interconnections between circadian rhythms and lipid metabolism. The research project, led by the University of Missouri System, will investigate three key knowledge gaps: 1) how phosphatidic acid (PA) mediates nuclear processes, 2) how PA and lipid...
- The federal Project Grant award of $420,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to identify the molecular mechanisms of mitochondrial dysfunction in pathological stress conditions. The primary objective is to investigate the processes of oxidative phosphorylation and mitochondrial membrane potential disruption, which can lead to cell death and tissue damage in various diseases....
- This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) of the National Institutes of Health (NIH), under the Environmental Health federal grant program (CFDA 93.113), supports research on the mechanisms of manganese-induced neurotoxicity via the leucine-rich repeat kinase 2 (LRRK2) protein. The $682,698 award to Florida A&M University (FAMU) aims to investigate how elevated manganese levels, as seen in occupational or environmental exposures, impact the...
- The National Science Foundation (NSF) awarded a $7,394,696 Project Grant under the STEM Education (CFDA 47.076) program to the Morehouse School of Medicine, Inc. (MSM) to establish a world-class research center for studying circadian rhythms and sleep. The 5-year project, titled "CREST PHASE I: CENTER FOR CIRCADIAN RHYTHMICITY AND SLEEP HOMEOSTASIS", aims to investigate how circadian disruptions affect the body, focusing on identifying the neuronal mechanisms responsible for...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), provides $390,500 to The Morehouse School of Medicine, Inc. (MSM) to investigate the role of melatonin signaling in regulating liver metabolism. The key objectives of this 2-year project are to: 1) produce liver-specific melatonin receptor type 1 (MT1) knockout mice to assess the effects of removing MT1 signaling only from the liver, and 2) explore how melatonin signaling regulates liver transcriptomics and associated biological pathways. This research aims to provide new insights into the importance of melatonin signaling in the liver and potentially inform the development of future pharmacological treatments.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $390.5k | 9/3/25 |