This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $656,751 to Third Coast Dynamics, Inc. to develop an artificial intelligence-based platform called "TCDFLOW" that can derive 4D hemodynamic data from routine clinical anatomic images. This will address limitations of current 4D flow MRI techniques, which require specialized equipment and expertise, by enabling the...
This National Science Foundation (NSF) Engineering (CFDA 47.041) Project Grant award to Worcester Polytechnic Institute (WPI) in the amount of $259,570 will develop 3D spheroid models using patient-derived trophoblast cells to investigate placental cell invasion and study preeclampsia, a pregnancy complication with high global maternal and infant mortality rates. The 2-year project will design culture conditions to maintain the spheroid models, engineer an extracellular matrix to mimic the...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $588,880 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to develop fast and accurate methods for reconstructing 3D fetal brain volumes from 2D MRI scans. The goal is to integrate these coherent 3D brain volumes and automated brain biometric...
The National Science Foundation (NSF) awarded a 3-year, $567,284 Project Grant under the Engineering program (CFDA 47.041) to Purdue University to develop a scalable Bayesian methodology for reconstructing cardiovascular hemodynamic flow fields and cardiac structure from advanced medical imaging modalities like phase-contrast MRI, 4D flow MRI, and color Doppler echocardiography. The research aims to overcome limitations in current imaging techniques, such as inaccurate velocity flow...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the federal Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $217,461.00 to the University of Illinois to develop an innovative "ChirpCFI" approach for color flow imaging (CFI) using ultrasound. The research aims to overcome limitations of traditional CFI methods by leveraging Doppler-tolerant hyperbolic chirp...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under CFDA Program 93.865 - Child Health and Human Development Extramural Research, will fund a computational modeling study to investigate uteroplacental hemodynamics and its implications for placental development and fetal health. The $766,982 award to Carnegie Mellon University will develop and validate a novel computational framework to simulate uteroplacental...
This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) aims to develop an AI-augmented, image-based hemodynamic modeling platform to enhance cardiovascular research and healthcare. The $150,000 award, effective September 1, 2024 through May 31, 2028, will be used by the University of Notre Dame to automate the transformation of medical images into 3D geometries for computational fluid...
This Project Grant from the National Heart, Lung and Blood Institute, part of the Department of Health and Human Services, provides $920,176 under the Cardiovascular Diseases Research program to develop a smart aspiration catheter with fiber optic pressure sensors for mechanical thrombectomy procedures to treat acute ischemic stroke. The catheter will be designed, prototyped and validated at Worcester Polytechnic Institute to provide real-time data to interventionalists on the interaction...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $376,250 to the California State University Long Beach Research Foundation to conduct research on the biomechanics and hemodynamics of the human aorta with remodeling after endovascular repair. The key objectives are to identify biomechanical features to characterize aortic remodeling triggered by extensive thoracic endovascular aortic...
This Project Grant award from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041 - Engineering) supports a $320,155 research project at Purdue University to investigate the complex flow and transport processes within microvascular networks and their impact on vascular remodeling. The key objectives are to develop a novel computational model integrated with high-resolution imaging data to gain fundamental understanding...