Imaging of human brain oxygenation and oxygen metabolism dynamics
Ended Project Grant Awarded Last action
- Award ID
- R21EB032485
- Recipient
-
University Of California, Davis UEI TX2DAGQPENZ5 Part of State Of California Controllers Office
- Awarding agency
-
National Institute of Biomedical Imaging and Bioenginering
National Institutes of Health, Department of Health and Human Services
- Obligated
- $864,477
Award facts
- Assistance listing
- 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health
- Completion date
- Originally
- Place of performance
- Davis, CA, USA
Award details come from USAspending.gov.
Description
- Abstract
- The human brain requires continual oxygen delivery to meet its enormous metabolic demand, and suffers devastating consequences when this oxygen supply is disrupted, as in stroke. While new endovascular treatments have shown promise to improve cerebrovascular outcomes, they are hampered by the lack of noninvasive biomarkers to stratify patients who are good candidates for these therapies. In particular, imaging of oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO2) is a long- recognized but unmet need in the stroke community. This project develops novel, clinically feasible tools for non-invasive oxygenation imaging, to study how the brain dynamically meets its oxygen needs and identify key pathophysiology in neurological patients. Our specific aims are (1) to enhance MRI-based reconstructions of OEF maps through novel "fingerprint matching" to microvascular voxel simulations and validation with the [15O]-oxygen gas pet reference; and (2) to develop a hybrid pet and MRI approach to rapidly image CMRO2 dynamics and its functional networks during a single resting scan. The novelty of this work lies in leveraging the unique capabilities of simultaneous pet/MRI scanners. The use of a pet/MRI system to validate and augment MRI-only methods for clinical OEF assessment with simultaneous pet scans is highly innovative. Hybrid measurements also allow for new, rapid CMRO2 imaging approaches that embody the best of each modality - fast and quantitative - to model brain functional connectivity and disease. Success of this proposal will generate novel neuroimaging tools to study brain oxygen consumption that are broadly applicable to any site with an MRI scanner. These advancements will enable use of physiological imaging biomarkers to evaluate endovascular therapies and reduce stroke risk, and enhance our fundamental neuroscience capabilities to understand the vascular underpinnings of brain function.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $239,473 | |
| Amendment | $198,666 | |
| Amendment | $213,169 | |
| Original award | $213,169 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Stanford Leland Junior University | $88,616 |
Quick answers
Who received award R21EB032485?
R21EB032485 was awarded to University Of California, Davis by National Institute of Biomedical Imaging and Bioenginering (National Institutes of Health) on September 30, 2022.
How much is award R21EB032485 worth?
$864,477 has been obligated on R21EB032485.
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