Project Grant R21EB021483

This federal Project Grant award of $984,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to test a novel treatment using sodium glucose co-transporter-2 (SGLT-2) inhibitor medications for the prevention of recurrent idiopathic calcium phosphate (CAP) kidney stones. The research, to be conducted at the University of Chicago from September 2025 to September...

This National Science Foundation (NSF) award under CFDA Program 47.041 - Engineering, provides $499,680 to the University of Houston System to elucidate the mechanisms by which organic and inorganic modifiers, such as citrate derivatives and salts, can dissolve calcite - the most stable and problematic form of calcium carbonate mineral scale. The 3-year project aims to: (1) determine the dissolution mechanisms of calcite scale, (2) examine the effects of flow on modifier-calcite interactions and...

This Project Grant award from the National Center for Advancing Translational Sciences (NCATS) under CFDA Program 93.350 provides funding of $437,761 to the University of Texas at Austin for a 2-year research project from August 2024 to July 2026. The project aims to determine if a human enzyme therapeutic that degrades cystine can prevent or slow the formation of cystine kidney stones and mitigate associated kidney pathology in a mouse model of cystinuria, a rare metabolic disorder causing...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, will fund research aimed at understanding the regulation of the calcium transporter SLC24A4 and its role in enamel formation. The $902,000 award to the University of California, San Francisco will support a 2-year investigation into the transcriptional and cellular mechanisms governing SLC24A4 expression in...

This Project Grant award, funded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041), will support research to derive a fundamental understanding of molecular interactions and toughening mechanisms in inorganic minerals for developing tough and durable structural materials. The key innovation is to turn ubiquitous calcium carbonate into a monolithic binder as an alternative to cement and concrete. This $0.00 award, with a project period from September 1, 2025...

This federal Project Grant award of $166,740 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is focused on defining the role of urinary phosphate in the progression of chronic kidney disease (CKD). The key products and services to be delivered through this 5-year award include: Determining how chronic phosphaturia (excessive urinary phosphate excretion) impacts CKD...

This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $636,261 to the University of Maryland, College Park to conduct research on harnessing molecular interactions and multi-bioinspired toughening in inorganic minerals for developing next-generation structural binders. The key innovation aims to transform ubiquitous calcium carbonate into a monolithic binder as a potential alternative to cement and concrete. The research will explore...

The National Science Foundation (NSF) awarded a Project Grant under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Hypogenica LLC in the amount of $304,901 on July 15, 2025. The project aims to scale a novel carbonate precipitation pathway in bacteria to produce industrially-relevant precipitated calcium carbonates (PCCs), which are an important filler used in paints, plastics, adhesives, and paper. This biological process offers a cost-effective and reliable...

The National Science Foundation awarded a $431,614 project grant to the University of Miami under the Engineering program (CFDA 47.041) to support research titled "MULTISCALE MECHANISMS OF DISSOLUTION AND REACTIVITY OF CALCIUM ALUMINOSILICATE GLASSES: TOWARDS RATIONAL DESIGN OF LOW-CARBON CEMENT SUBSTITUTES." The three-year award, which runs from May 2021 through April 2024, will fund research exploring calcium aluminosilicate glass dissolution and reactivity to enable more sustainable...

This Project Grant award of $305,368 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop a magnetic retrieval system for removing kidney stone fragments. The project, led by Maguro Surgical Inc., aims to create a "MagStone" system that can more effectively remove residual kidney stone fragments left after surgery compared to the current...