This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is focused on developing an off-the-shelf biomaterial that can regenerate craniofacial bone defects of any shape or size. The $300,155 award to Colorado State University aims to evaluate the osteoinductivity of recently identified peptides and screen promising new peptides identified through a peptide microarray approach. The goal...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $429,000.00 to the Regents of the University of Michigan to conduct research on the unique characteristics of jawbone biology. The research aims to gain a molecular-level understanding of how osteoblasts in the jawbone respond differently to bone morphogenetic protein (BMP) signaling and mechanical loading...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), is focused on regeneration of alveolar bone tissue. The $476,287 award aims to investigate the role of the MERTK receptor tyrosine kinase in regulating early bone formation and its potential as a therapeutic target for alveolar bone regeneration. Specific objectives include determining the effects of MERTK...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded Cayman Chemical Co Inc. a $613,736 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop novel osteogenic small-molecule pharmacotherapies for local delivery to stimulate alveolar bone regeneration. Through this award, Cayman Chemical will use an artificial intelligence-driven system to design, synthesize, and test EZH2 inhibitor compounds that can promote bone formation, with the...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program provides $456,500.00 to the University of Southern California (USC) to conduct research on periodontal tissue regeneration. The key focus is to investigate the use of a supramolecular nanomaterial called peptide amphiphile (PA) to enhance the regenerative effects of the bioactive peptide leucine-rich amelogenin peptide...
This federal Project Grant award, valued at $161,762.00 and awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research on the role of the NG2/CSPG4 protein in the healing of endochondral fractures in the mandible. The research aims to define the specific molecular pathways by which NG2/CSPG4 regulates the differentiation of osteochondral progenitor cells during fracture repair, with the...
This Project Grant award of $690,625.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), supports research to explore the use of the FDA-approved iron oxide nanoparticle formulation ferumoxytol to activate and promote the regenerative capabilities of orofacial mesenchymal stem/progenitor cells (OMSCs). The key objectives are to determine how ferumoxytol activates the YAP/TAZ signaling...
This Project Grant award of $3,069,994.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), supports a research program focused on investigating skeletal stem cell plasticity as a central mechanism underlying craniofacial bone diseases. The research aims to elucidate the roles of periosteal, endosteal, and chondrocyte stem cells in intramembranous and endochondral craniofacial bone...
This $672,394.58 project grant from the National Institutes of Health's National Institute of Dental and Craniofacial Research Oral Diseases and Disorders Research program (CFDA 93.121) supports the development of a crosslinkable tissue particle implant for regenerating craniofacial bone. Led by Leefa Biotech LLC, the one-year award aims to demonstrate improved bone regeneration in critical-size cranial bone defects using the implant compared to the current standard of care. If successful, the...
This Project Grant award of $588,952 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is focused on developing a bio-inspired scaffold called "PerioPatch" to regenerate Sharpey's fibers and periodontal tissues. The key objectives are to: 1) develop and optimize a tubular matrix to guide periodontal ligament (PDL) principal fiber formation, 2) rebuild the microenvironment for Sharpey's fiber...