Mechanisms of mitral cell regeneration in zebrafish
Active Project Grant Awarded Last action
- Award ID
- R21DC022365
- Recipient
-
The Morgridge Institute For Research, Inc. UEI W6Q8XJV41Z98
- Awarding agency
-
National Institute on Deafness and Other Communincation Disorders
National Institutes of Health, Department of Health and Human Services
- Obligated
- $495,000
Award facts
- Assistance listing
- 93.173 Research Related to Deafness and Communication Disorders
- Completion date 61% complete
- Place of performance
- Madison, WI 53715, USA
Award details come from USAspending.gov.
Description
- Abstract
- The human brain cannot efficiently regenerate neural tissue after injury or stroke. By contrast, zebrafish possess a striking ability to regenerate injured adult brain tissue from resident neural stem cell populations. The cellular dynamics controlling this phenomenon are unclear and understudied. In this proposal, we will employ a new precision injury tool we developed to dissect the cellular dynamics and mechanistic properties that underly brain regeneration. With this tool, we will genetically induce targeted ablation of specialized neurons called mitral cells in the adult zebrafish olfactory bulb. In preliminary studies, we used this tool to show that after precise ablation, mitral cells of the olfactory bulb regenerate cell bodies and long axons that project to deeper brain centers. Moreover, single-cell transcriptomic analysis during the regeneration time window indicates extensive and dynamic robustness events of the olfactory bulb during mitral cell regeneration. We propose to: 1) interrogate the robustness and neuronal plasticity of the olfactory bulb during regeneration of a precision injury model; and 2) define the molecular basis for mitral cell regeneration in zebrafish. Our work will provide a new view of regenerative capacity in the context of brain injury and a better understanding of the events that surround regeneration of specialized neurons.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Original award | $495,000 |
Quick answers
Who received award R21DC022365?
R21DC022365 was awarded to The Morgridge Institute For Research, Inc. by National Institute on Deafness and Other Communincation Disorders (National Institutes of Health) on August 1, 2025.
How much is award R21DC022365 worth?
$495,000 has been obligated on R21DC022365.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award