Project Grant R21CA291905

Award Date 7/1/25
Completion Date 6/30/27
Dollars Obligated $426K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
This Project Grant award, provided by the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), will fund a pilot study to evaluate the associations of pre- and post-chemotherapy and -radiotherapy gut microbiome profiles with breast cancer recurrence and mortality. The $175,000 award will support the use of shotgun metagenome sequencing on 110 post-treatment stool samples from the Vietnam Breast Cancer Study, as well as an investigation of the impact of...
This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research program) provides $537,985 to the University of Texas MD Anderson Cancer Center to deeply characterize the location, distribution, and spatial functionality of microbes within the tumor microenvironment of primary pancreatic ductal adenocarcinoma (PDAC) tumors, as well as their influence on tumor growth, pre-metastatic niche formation, and liver metastasis. The research will utilize...
The U.S. National Cancer Institute (NCI) awarded a $450,000 Project Grant under the CFDA 93.396 Cancer Biology Research program to The Research Foundation for the State University of New York, doing business as Stony Brook University. The project, titled "Topological Methods for Breast Tissue Quantification," aims to develop advanced algorithms and analytical techniques using topological data analysis (TDA) to extract and interpret fine-grained structural information from breast...
This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to the University of Pittsburgh aims to investigate how immune checkpoint inhibitor-associated bacteria can modulate tumor immunity and improve the efficacy of immune checkpoint inhibitor (ICI) therapies in treating melanoma. The $636,222 grant, awarded on April 1, 2025, with a completion date of March 31, 2030, will support research to: 1) test whether ICI-associated bacteria can...
This Project Grant award, valued at $150,701.00 and provided by the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program), aims to investigate the relationship between diet, gut microbiome, and cancer treatment-related cognitive impairment (CRCI) in breast cancer survivors (BCS) undergoing chemotherapy. The key objectives are to: 1) determine the relationship between components of a Mediterranean diet, gut microbiome, and cognitive function in 30 BCS before, during, and...
This Project Grant award from the National Cancer Institute (NCI), under the Cancer Treatment Research program (CFDA 93.395), provides $606,839 to Weill Medical College of Cornell University to study the role of microbiota amino acid metabolism in cancer. The project aims to identify gut microbes and their genes that deplete intestinal amino acids, and evaluate how they affect the tumor microenvironment and cancer progression. The 5-year project will combine bioinformatics, metabolomics,...
The National Cancer Institute (NCI) awarded a $954,000 Project Grant (CFDA 93.396 - Cancer Biology Research) to the University of Pittsburgh to investigate how aging promotes the growth of glioblastoma, one of the most lethal forms of cancer. The research aims to leverage insights from the biology of neural stem cells and the molecular circuitry of cancer stem cells to understand how aging creates a tumor microenvironment that supports the survival and proliferation of glioblastoma. The...
This $222,027 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research (CFDA 93.396) program supports the development of a novel computational imaging algorithm to characterize the mechanobiology of three-dimensional tumor microenvironments (TMEs). The University of Pittsburgh, the grant's recipient, aims to combine high-resolution digital pathology imaging and highly multiplexed immunofluorescence microscopy with physical optics-based principles to...
This federal Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) provides $678,399 to The University of Texas MD Anderson Cancer Center to conduct a prebiotic diet intervention study. The goal is to evaluate whether a prebiotic-enriched diet can enhance the gut microbiome and improve response to immune checkpoint inhibitor (ICI) therapy in patients with metastatic melanoma. The 5-year study will investigate the...
This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $221,456.00 to the Regents of the University of Minnesota to develop and optimize a novel approach for enriching microbes from clinical cancer samples. The goal is to enable deep metaproteomic analysis to better understand how non-host microorganisms influence carcinogenesis and cancer treatment. The 3-year project will pursue two specific aims: 1) optimizing and...

The National Cancer Institute (NCI) awarded a $425,573 Project Grant (CFDA 93.395 Cancer Treatment Research) to Magee-Womens Research Institute and Foundation located in Pittsburgh, Pennsylvania. The grant will fund a 2-year study (July 1, 2025 - June 30, 2027) to identify gut bacteria species, metabolites, and metabolic pathways associated with high mammographic breast density (MBD). The goal is to provide insights into modifiable factors that contribute to high MBD, which is a significant risk factor for breast cancer. The researchers will use multi-omics analyses and AI-based imaging to quantify MBD and compare gut microbiome composition and serum metabolites between women with high versus low MBD. The findings have the potential to inform the development of personalized breast cancer surveillance and prevention strategies by identifying gut bacteria that can serve as intervention targets to reduce MBD.

Generated 7/15/25, 9:28 AM