Car mast cell for solid tumor
Ended Project Grant Awarded Last action
- Award ID
- R21CA286364
- Recipient
-
Yale Univ UEI FL6GV84CKN57
- Awarding agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,098,706
Award facts
- Assistance listing
- 93.395 Cancer Treatment Research
- Completion date
- Place of performance
- Connecticut, USA
Award details come from USAspending.gov.
Description
- Abstract
- Chimeric antigen receptor (car)-t cell therapies have achieved unprecedented success in treating blood cancers that are resistant to traditional radiation or chemotherapies. However, the efficacy of car-t therapy to solid tumors remains limited. Major challenges include poor infiltration of t cells into tumors, exhaustion and low persistence of t cells under a hostile tumor environment. To tackle these problems, we aim to seek alternative cell carriers for car. Mast cells present several advantages in targeting solid tumors: they reside in tumor tissues and can live up to years. They can repetitively kill target cells without exhaustion. They also release cytokines that can recruit other effector cells to kill cancer. In this project, we will design cars that specifically activate mast cells to kill solid tumors, using melanoma and colon cancer as models. Our efforts are expected to lay the scientific foundation for a brand-new cell therapy, and provide rationales and generate reagents for moving towards further pre-clinical and clinical studies.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | -$60 | |
| Amendment | $19,665 | |
| Amendment | $176,981 | |
| Amendment | $176,981 | |
| Amendment | $241,713 | |
| Amendment | $241,713 | |
| Original award | $241,713 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Liberty University Inc. | $64,134 |
Quick answers
Who received award R21CA286364?
R21CA286364 was awarded to Yale Univ by National Cancer Institute (National Institutes of Health) on February 2, 2024.
How much is award R21CA286364 worth?
$1,098,706 has been obligated on R21CA286364.
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