Project Grant R21AR088391
- The National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Rush University Medical Center $643,185 on June 10, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award funds development of validated, patient-specific computational models to predict polyethylene wear in total shoulder arthroplasty (TSA) and identify modifiable surgical, design, and rehabilitation targets to improve implant...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Texas at Arlington $711,976 on May 15, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to develop and validate D-glutamine PET imaging radiotracers for early detection and precision treatment monitoring of orthopedic implant infections caused by gram-positive and gram-negative bacteria. Current PET radiotracers have significant limitations: [18F]FDG...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University School of Medicine $396,206 on September 1, 2026, to develop and validate a radiogenomic virtual biopsy approach for femoroacetabular impingement (FAI) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The project tests feasibility of linking routine magnetic resonance imaging features to bone gene expression patterns in FAI patients to enable noninvasive...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded $1.696 million to Poly Orth International on September 15, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award funds translational pre-clinical research and development of a 3D-printed skin and bone integrated pylon (SBIP-3D) for direct skeletal attachment of limb prostheses. The technology, developed by Poly Orth International, integrates with both residual bone...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Johns Hopkins University $569,402 on July 2, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate clinical heterogeneity in immune checkpoint inhibitor-induced inflammatory arthritis. The recipient will conduct prospective clinical studies leveraging the RADIOS (Rheumatology Adverse Events due to Immunotherapy Observational Study) cohort, a multicenter USA...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded $547,767 to the University of Rochester on June 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate host mechanisms governing Staphylococcus aureus persistence during implant-associated osteomyelitis. The research uses humanized mouse models and multi-omic analysis of human T cells to understand why some patients resolve acute bone infections while others...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded $602,113 to the University of Texas at San Antonio on May 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to develop and test a nanomedicine platform for treating rotator cuff tears complicated by fatty infiltration in muscle tissue. The award supports research into lipid-coated mesoporous silica nanoparticles loaded with forskolin (LCMSN/FSK), a therapeutic approach...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded $676,210 to The Washington University on August 5, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The recipient will conduct research into DNMT3A as an epigenetic transcriptional therapeutic target in femoroacetabular impingement (FAI) progression to osteoarthritis. FAI is a pre-arthritic hip condition affecting individuals aged 20 to 40; standard surgical treatment...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University $148,062 on September 30, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The funded research investigates the mechanism by which epithelial stem and progenitor cells encode inflammatory memory in psoriasis and other remitting-relapsing inflammatory disorders. The study tests whether homeostatic and inflammatory transcription factors dynamically...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Regents of the University of Colorado $578,289 on September 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846, Assistance Listing R01AR086835). The award funds translation and validation of DualMRI (Displacements Under Applied Loading by MRI), a noninvasive imaging method to measure articular cartilage biomechanics and predict pre-osteoarthritis pathogenesis in...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Rush University Medical Center $366,988 on September 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to develop a rapid detection tool for Cutibacterium acnes infection on shoulder implants using Raman spectroscopy. The project establishes a diagnostic method to identify C. acnes biofilms on removed shoulder arthroplasty implants by analyzing their chemical composition via high-resolution and high-throughput Raman spectroscopy. The work addresses a critical clinical gap: C. acnes infections are difficult to diagnose due to the organism's slow growth and culture false-positive rates, yet positive C. acnes cultures appear in 59–100% of aseptic shoulder revision surgeries, suggesting unrecognized biofilm-driven implant failure. The ultimate goal is a point-of-care diagnostic tool to confirm C. acnes and other infections intra- or peri-operatively and clarify C. acnes's role in implant loosening. Performance occurs in Chicago, Illinois, with a period of performance from September 1, 2026, through August 31, 2028. The assistance type is Project Grant (R21AR088391).
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $367.0k | 8/24/26 |