Project Grant R21AR085243
Award Date
4/1/25
Completion Date
2/28/27
Dollars Obligated
$222K
Federal Grant Program
93.846
Assistance Type
Project Grant
Place of Performance
Farmington, CT 06030, USA
Similar Awards
This Project Grant award, with a total funding amount of $412,610.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The objective of the research is to better understand how peripheral blood microbiome patterns are associated with knee osteoarthritis (OA). The work aims to determine whether differences in baseline peripheral blood bacterial DNA patterns...
This $347,056 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to evaluate the role of vitamin K in knee osteoarthritis outcomes. The key objectives are to:
Assess blood thresholds of vitamin K associated with increased risk of structural osteoarthritis outcomes, and the potential of matrix Gla protein as a serum...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $578,944 to the University of Alabama at Birmingham (UAB) to conduct research on the genetics of osteoarthritis susceptibility, heterogeneity, and progression. The key objectives are to: 1) identify new and fine-map known genetic loci associated with osteoarthritis and joint replacement...
This three-year, $906,000 project grant from the National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases will fund research into obesity-promoting protein malonylation and its role in chondrocyte metabolic dysfunction and osteoarthritis development. Specifically, the grantee - Ohio University - will investigate how obesity accelerates osteoarthritis through "carbon stress," which causes metabolic byproducts to accumulate in cartilage...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $571,650 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the University of Pittsburgh to repurpose FDA-approved drugs for the treatment of osteoarthritis (OA). The goal is to use high-throughput screening in human cell-derived microphysiological models to identify FDA-approved drugs that can reverse cartilage and/or inflammation-driven OA endotypes. The project...
This $644,152 project grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research to determine the mechanistic link between limb-level loading during gait and the development of knee osteoarthritis. The primary objectives are to:
Evaluate the acute in vivo effects of sustained versus dynamic limb-level loading on mechanical and biophysical...
This $359,207 Project Grant award was made by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The goal of this 4-year research project is to develop optical redox imaging (ORI)-based medical instruments that can diagnose cartilage disease and evaluate therapeutic approaches for osteoarthritis (OA). The award will fund the development of a stress test to diagnose cartilage...
This federal Project Grant award of $456,808 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskelastic and Skin Diseases Research program (CFDA 93.846), will fund the development of innovative mass spectrometry imaging (MSI) technologies to spatially visualize proteins and glycans in bone and cartilage tissue samples. The project aims to advance understanding of disease progression in osteoarthritis and meniscal injury by...
This federal Project Grant award of $410,920 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research to investigate risk factors for end-stage glenohumeral (shoulder) osteoarthritis. The key objectives are to: 1) determine associations between occupational exposures and osteoarthritis-related shoulder arthroplasty risk, 2) identify genetic variants...
This $350,000 federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to investigate the therapeutic role of the NFAT1 transcription factor in osteoarthritis (OA) development. The research will be conducted by the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) from August 1, 2024 to July 31, 2029.
Specifically, the research project will (1) evaluate the...