Project Grant R21AI199683
- The National Institute of Allergy and Infectious Diseases awarded Western University of Health Sciences $144,000 on June 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how HIV accessory proteins VPU and NEF target the IPS-1 adaptor protein, leading to its degradation and inhibition of type I interferon production. The research examines the mechanism by which HIV manipulates the interferon system to evade immune detection and persist in the host,...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services, awarded Western University of Health Sciences $540,000 on July 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate protein kinase R's role in hantavirus organ tropism. The research examines how Old World hantaviruses (Puumala, Seoul, and Dobrava Belgrade viruses) selectively infect kidney microvascular endothelial cells causing...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $725,778 on August 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate alphaherpesvirus axonal transport and neuroinvasion mechanisms. The research deciphers how neuroinvasive herpesviruses such as herpes simplex virus type 1 and pseudorabies virus invade the nervous system to establish lifelong latent infections; identifies intrinsic barriers to neural...
- The National Institute of Allergy and Infectious Diseases awarded the University of California Irvine $301,936 on January 16, 2026, for Project Grant F32AI194808 under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research investigating the role of cystatin F expression on microglia in constraining demyelination following viral infection of the central nervous system. The research uses a murine neurotropic JHM strain of mouse hepatitis virus (JHMV) model...
- The National Institute of Allergy and Infectious Diseases awarded the University of Kentucky Research Foundation $231,000 on August 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the regulation of interferon regulatory factor 7 (IRF7) by an inducible protein phosphatase. The research defines molecular mechanisms by which the phosphatase regulatory subunit 2R1B and its catalytic partners regulate IRF7 phosphorylation and antiviral gene...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded $235,500 to the University of California Irvine on February 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for Project Grant R21AI196970. The award funds research on the molecular architecture of the vaccinia virus factory, with emphasis on characterizing protein interactions at the molecular level during virion morphogenesis. The research...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, Los Angeles $196,020 on July 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to define distinct mechanisms of interferon gamma trained immunity. The research investigates how interferon gamma (IFNG), a cytokine secreted by T cells in response to infection, drives trained immune memory—the ability of innate immune cells to retain memory of prior stimuli. The project...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded $120,312 to the University of California, Berkeley on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into adenosine deaminases acting on RNA (ADARs), enzymes that edit RNA to regulate gene expression and immune responses. The research aims to identify viral and host...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Southern California a Project Grant of $831,235 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 21, 2025, with a project completion date of July 31, 2030. This research initiative aims to develop a broad-spectrum antiviral therapy by targeting a key nucleotide synthesis enzyme that diverse viruses—including SARS-CoV-2, Herpes Simplex Virus 1...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3.05 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Virginia on September 12, 2025, with a completion date of August 31, 2029. This research initiative investigates paired receptor signaling in natural killer (NK) cells to understand antiviral immunity and viral control mechanisms. The project employs advanced molecular...
The National Institute of Allergy and Infectious Diseases awarded Western University of Health Sciences $200,600 on August 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate noncanonical DNA virus sensing through an IKK-alpha-driven interferon signaling cascade. The research project maps a previously unrecognized antiviral signaling pathway that bypasses the canonical cGAS-STING-TBK1-IRF3 axis and instead utilizes IKK-alpha to drive type I interferon responses in gammaherpesvirus-infected cells. The work employs knockout mouse cells, RNA-sequencing, biochemical interaction studies, and reporter assays to identify upstream viral DNA sensors, define critical transcription factors, and characterize how gammaherpesviruses such as murine gammaherpesvirus 68, Epstein-Barr virus, and Kaposi's sarcoma-associated herpesvirus engage this pathway. The discovery would demonstrate that antiviral interferon responses can persist even when canonical pathways are blocked by viral evasion mechanisms, potentially explaining how hosts maintain immune surveillance under viral pressure and pointing to novel therapeutic strategies targeting this alternate system. Performance occurs at Western University of Health Sciences in Pomona, California, with a period of performance from August 7, 2026, through July 31, 2028. The funding is classified as a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $200.6k | 8/7/26 |