Project Grant R21AI194001
Award Date 9/16/25
Completion Date 8/31/27
Dollars Obligated $284K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
2323 Riverside Dr., Ottawa, ON K1H 1A1, Canada
Similar Awards
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $451,956 Project Grant on August 15, 2025 to Baylor College of Medicine under the Allergy and Infectious Diseases Research program (CFDA 93.855) to study the mechanisms by which the syphilis-causing bacterium Treponema pallidum invades and impacts the placenta. The project aims to use novel in vitro models of trophoblast cells and organoids to characterize T. pallidum attachment, growth, and internalization, as well as...
- This Project Grant award of $448,150 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to explore how the syphilis-causing bacterium Treponema pallidum avoids complement-mediated killing by recruiting the human complement inhibitor Factor H. The goal is to improve understanding of syphilis pathogenesis and identify new control strategies, as syphilis remains a public health concern...
- This federal Project Grant award of $445,250.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to establish a mouse model of congenital syphilis (CS) and determine changes in the host immune response. The primary goals are to lay the foundation for developing improved diagnostics and vaccines for syphilis, a sexually transmitted disease with increasing global incidence. The grant, awarded to...
- This Project Grant award of $418,360.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Program (CFDA 93.855), aims to systematically analyze Treponema pallidum gene expression under host infection-related conditions. The central hypothesis is that T. pallidum, the bacterium that causes syphilis, alters its gene expression in response to changes in oxygen concentration, temperature, and host interactions, which enables...
- This $698,349 Project Grant awarded on February 25, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports the development of an "Integrated Multiplexed Diagnostic Assay Targeting Fusion Lipoproteins and Cardiolipin for Detection of Treponemal and Nontreponemal Antibodies in Syphilis Patients." The goal is to create a rapid, point-of-care diagnostic test that can definitively diagnose...
- The University of Connecticut Health Center (UCHC) was awarded a $457,875 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate fundamental aspects of syphilis disease pathogenesis, including nutrient acquisition and environmental sensing by the bacteria Treponema pallidum. The grant, which spans from August 1, 2025 to July 31, 2027, will support research activities to...
- The University of Washington was awarded a $485,375 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant, awarded on August 11, 2025, will fund research to elucidate the role of genetic recombination in Treponema pallidum, the bacterium that causes syphilis. Specifically, the researchers will investigate the mechanisms of homologous recombination in T. pallidum and examine...
- The federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), will provide $511,763 to Seattle University to conduct activity-based protein profiling of the vaginal microbiome. The goal is to understand how enzymes related to glycogen degradation and microbial proteases are associated with vaginal community composition and bacterial vaginosis. The 3-year project,...
- This federal Project Grant award of $243,750 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate how the bacterium Gardnerella promotes the pathogenesis of Neisseria gonorrhoeae, the causative agent of the sexually-transmitted infection gonorrhea. The key objectives are to determine the mechanisms by which Gardnerella virulence factors, including the cytolytic toxin...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $404,273 to Virginia Commonwealth University (VCU) to conduct research on the effects of the bacteria Sneathia vaginalis on the amnion, which could play a role in preterm birth and premature rupture of membranes. The key goals of the project are to characterize the damage Sneathia vaginalis causes to the...
This federal Project Grant award of $283,694 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by Dalhousie University to investigate how the syphilis bacterium, Treponema pallidum, interacts with the cervicovaginal epithelial barrier and whether the vaginal microbiome influences susceptibility to T. pallidum infection. The research aims to advance the understanding of syphilis transmission dynamics and identify potential interventions, such as probiotics or postbiotics, that could help reduce the burden of infectious and congenital syphilis. This work is expected to run from Sep 2025 through Aug 2027.
Generated 10/21/25, 6:55 AM
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $283.7k | 9/16/25 |