Federal Grant Award Summary

The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Pennsylvania State University a $247,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) beginning May 1, 2026 and concluding April 30, 2028. This research initiative applies advanced reverse genetic, transcriptomic, proteomic, and microscopy-based approaches to investigate the mechanisms of translational repression control in Plasmodium parasites during the critical transmission window between mammalian hosts and mosquito vectors. The research addresses a fundamental gap in understanding how malaria parasites regulate gene expression to facilitate infection establishment in mosquitoes.

The project deliverables include the identification and validation of molecular triggers that initiate the release of translational repression in female parasites, specifically examining the contributions of male gametocytes and gametes to this process. Through reverse genetics and protein-based blocking methodologies, the research will characterize the regulatory mechanisms controlling translational control and generate scientific knowledge applicable to disrupting parasite transmission and infection establishment. Findings are intended to inform novel intervention strategies against malaria, a disease identified as maintaining significant global disease burden.