This federal Project Grant award, totaling $215,810.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to identify host proteins degraded in neurons by the Herpes Simplex Virus (HSV-1) and the roles of the viral proteins ICP0 and PUL55/PUL13/PUS10 in protein degradation and viral reactivation from latent infection. The primary awardee is the Rector & Visitors of the University of Virginia, which will collaborate with a sub-awardee, the University of Cambridge, to conduct the research. The University of Cambridge team, led by Professor Colin Crump, has expertise in quantitative mass spectrometry of virus-infected cells and generating HSV-1 mutant viruses. Their work will contribute to the overall goals of identifying host proteins degraded in neurons and determining how ICP0 and the PUL55 complex contribute to protein degradation and viral reactivation. The award commenced on November 8, 2024 and is scheduled for completion by October 31, 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $215.8k | 11/8/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
GR103662SUB00001292S | The Chancellor, Masters, And Scholars Of The University Of Cambridge | Project Grant R21AI183192 | $58.0k | 1/10/25 |