Impact of tuberculosis on the HIV reservoir
Ended Project Grant Awarded Last action
- Award ID
- R21AI170232
- Recipient
-
University Of Ghana Medical Centre UEI JMBGNZTS27A7
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $432,324
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date
- Originally
- Place of performance
- Ghana
Award details come from USAspending.gov.
Description
- Abstract
- Even though antiretroviral therapy (art) can suppress HIV and increase life expectancy, IT does not provide cure. Patients must commit to daily medications and deal with side effects, unsustainable costs and drug resistance. The main obstacle to an HIV cure is persistent provirus in the resting CD4+ t cell reservoir which produce virus under the right stimulation conditions. The most popular approaches for HIV cure or remission such as the shock and kill approach, broadly neutralizing antibodies, chimeric antigen receptors and therapeutic vaccines will all require some form of reactivation of the latent provirus. However, tuberculosis, an important factor that could affect the viral reservoir and its response to latency reversing agents (lras) has not received much attention in the context of HIV cure research. Over a third of HIV patients are infected with TB. Tuberculosis, including latent TB infection (ltbi), produces antigens that stimulate t cells, which could result in proliferation and alter the response of the reservoir to lras. Persistent stimulation could also result in t cell exhaustion. We are working with the hypothesis that TB antigens in the blood of CO-infected patients stimulate t cells to increase the size of the reservoir and alter the responses of CD8+ and CD8+ t cells. We will investigate this hypothesis with the following specific aims: aim 1: identify differences in t cell responses between HIV and HIV/LTB patients. We hypothesize that in CO- infected patients, CD4+ t cells will have decreased responses to LRA and CD8+ t cells will have reduced killing ability upon stimulation. First, we will compare the baseline activation status of resting t cells from virologically suppressed patients (VL
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $143,586 | |
| Amendment | $143,586 | |
| Original award | $145,152 |
Quick answers
Who received award R21AI170232?
R21AI170232 was awarded to University Of Ghana Medical Centre by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on March 22, 2022.
How much is award R21AI170232 worth?
$432,324 has been obligated on R21AI170232.
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