Project Grant R21AI139777

This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the CFDA 93.865 Child Health and Human Development Extramural Research program, provides $2,474,368 to evaluate the long-term medical, developmental, and mental health outcomes for children with Congenital Zika Syndrome (CZS) and their families. The award extends a successful collaboration between RTI International, Altino Ventura Foundation, University of North Carolina, and Purdue...

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $783,388 to Virginia Polytechnic Institute & State University (Virginia Tech) to conduct research on the mechanisms of Zika virus shedding in semen and sexual transmission. The key objectives are to: 1) Determine the role of Zika virus structural genes in acute viral shedding in semen, and 2) Determine the role of immune cells in...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,613,015.00 in funding to the University of Washington to study the impact of maternal Zika virus infection on fetal immune response and brain development. The key objectives are to: 1) Define the effects of maternal viral infections and inflammation on the development of fetal innate and adaptive immunity in the...

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports research to identify human genetic variants that confer susceptibility or resistance to Zika virus infection. The $418,927 award, active from June 2024 to April 2026, will fund the development of a high-throughput screening approach called SCHI-HOST to measure inter-individual variation in cellular infection phenotypes. This...

This $699,339 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports a multi-year research project to study the transmission dynamics of dengue and Zika viruses in Northwestern coastal Ecuador. The project aims to characterize the regional transmission patterns and drivers across human populations and mosquito vectors within diverse ecological, social, and transportation...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $431,750 R21 project grant (CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders) to Rutgers, The State University of New Jersey to study the role of the RIPK3 protein in protecting neurons from excitotoxicity during Zika virus infection. The two-year project will use a combination of pharmacogenetics, imaging, molecular biology, and electrophysiology to investigate how RIPK3...

This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop a novel vaccine to protect against maternal-to-fetal transmission of Zika virus (ZIKV). The total award amount is $1,701,891.00 with a project period from Jun 7, 2024 to Apr 30, 2029. The key objectives are to: 1) Improve vaccine-induced protection against ZIKV infection during pregnancy and...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $925,650 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Emory University to investigate host factors that contribute to positive-strand RNA virus-induced membrane reorganization. The research aims to define the role of host membrane proteins in the formation of viral replication organelles for the flaviviruses dengue virus and Zika virus, and to mechanistically interrogate the...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $234,359.00 to The Washington University in St. Louis to investigate the role of the MERTK receptor in cognitive and behavioral deficits associated with congenital Zika virus infection. The research aims to understand how increased MERTK signaling during Zika virus...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is providing $1,617,200.00 to the University of Arizona to conduct research focused on understanding the role of B cells in HIV persistence and expression during antiretroviral therapy (ART). The key objectives are to: 1) Determine the location, phenotype, and microenvironment of HIV RNA-expressing cells in secondary lymphoid...