Project Grant R21AG104110
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $441,460 to The Medical College of Wisconsin, Inc. on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate P66SHC signaling in cerebrovascular impairment associated with Alzheimer's disease. The award funds research testing the hypothesis that adaptor protein P66SHC signaling contributes to cognitive deficiencies and loss of cerebral vascular...
- The National Institute on Aging awarded the University of Virginia $2.877 million on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate microglia's role in neurovascular coupling and hypertensive cerebral small vessel disease. The project will test the hypothesis that microglial dysregulation of cerebral blood flow leads to hypertensive vascular dementia and endothelial rarefaction as common pathological events with Alzheimer's disease. Aim 1 will employ laser speckle...
- The National Institute on Aging awarded the University of Arizona $996,193 on July 15, 2026, under the Aging Research program (CFDA 93.866) to evaluate how small and large vessel cerebrovascular disease interact over time to contribute to Alzheimer's disease and related dementias risk. The project will examine how extracranial large vessels, intracranial large vessels, and cerebral small vessels interact across different patient populations, with particular attention to sex-specific...
- The National Institute on Aging, a component of the Department of Health and Human Services National Institutes of Health, awarded the University of Wisconsin System Office of Sponsored Programs (operating as University of Wisconsin–Milwaukee) $642,805 under the Aging Research program (CFDA 93.866) on January 15, 2026. The award funds three experiments investigating how older age affects memory integration—the ability to generalize across experiences, make inferences, and accumulate knowledge....
- The National Institute on Aging awarded The Medical College of Wisconsin, Inc. $645,037 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate microbial and neurovascular predictors for subtypes of prodromal Alzheimer's disease. The project examines the interactions between gut microbiota, neurovascular dysfunction, Alzheimer's disease biomarkers, and clinical progression in prodromal AD. The research tests the hypothesis that microbial agents—bacteria, viruses,...
- The National Institute on Aging awarded Rush University Medical Center $656,503 under CFDA 93.866 (Aging Research) on September 1, 2026, to develop and validate an in-vivo MRI-based classifier for detecting cerebral amyloid angiopathy in community-dwelling older adults. The project combines multimodal MRI imaging with neuropathological data to create a machine-learning classifier capable of identifying cerebral amyloid angiopathy—a common age-related pathology affecting up to 80 percent of older...
- The National Institute on Aging awarded $768,024 to the University of Wisconsin System (University of Wisconsin – Madison) on September 1, 2026, under the Aging Research program (CFDA 93.866) to fund a project grant studying psychosocial, behavioral, and neuropsychological responses to learning amyloid and tau biomarker results in cognitively unimpaired or mildly impaired adults at risk for Alzheimer's disease. The project will enroll 240 participants (including 25 percent Black/African American...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Pittsburgh $2,003,400 on September 15, 2025, under the Aging Research program (CFDA 93.866) to characterize white matter injury in Alzheimer's disease. The research investigates risk factors for and consequences of white matter injury in brain regions affected by Alzheimer's pathology using a novel, spatially precise measurement method called unhealthy...
- The National Institute on Aging awarded Marquette University $309,000 on May 15, 2026, under the Aging Research program (CFDA 93.866) to conduct longitudinal imaging studies in a preclinical Alzheimer's disease model aimed at identifying early biomarkers of cognitive decline. The project uses in vivo calcium imaging of prefrontal cortical neuronal ensembles and two-photon imaging of amyloid-beta deposits in a transgenic rat model to track changes in genetically defined excitatory and...
- The National Institute on Aging awarded the University of California, San Diego $674,455 on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of vascular sphingolipid metabolism in Alzheimer's disease. The research examines how cerebral blood vessels change in Alzheimer's disease patients through mass spectrometry-based proteomics and lipidomics analysis. Prior work identified downregulation of lipid metabolic enzymes and altered lipid composition in brain...
The National Institute on Aging awarded the University of Wisconsin-Madison $427,625 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate cerebral small vessel disease pathways in vascular contributions to cognitive impairment and dementia and Alzheimer's disease using ferumoxytol-enhanced MRI. The research will employ novel microvascular biomarkers including quantitative characterization of vascular density and hemodynamic measures of microvascular pulsatility to detect early microvascular dysfunction underlying cerebral small vessel disease, addressing a gap in understanding vascular vulnerabilities that may influence amyloid-related imaging abnormalities risk in mixed dementia populations. The single-visit study will enroll cognitively unimpaired individuals and examine how specific vascular processes contribute to cerebral small vessel disease in individuals with mixed vascular contributions to cognitive impairment and dementia and Alzheimer's disease burden. Work is performed in Madison, Wisconsin, with a period of performance from September 1, 2026, through August 31, 2028. This is a Project Grant, an exploratory/developmental award mechanism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 8/31/26 |