Project Grant RF1AG096337
- Federal Project Grant Award Summary The University of Virginia received a $242,250 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, awarded February 1, 2026, with a completion date of January 31, 2028. The research will be conducted in Charlottesville, Virginia, and focuses on investigating myeloid cell regulation of cerebrovascular tone and function...
- Federal Project Grant Award Summary Oregon Health & Science University has been awarded $471,885 by the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct a two-year research project (Award Date: June 1, 2025; Completion Date: May 31, 2027) investigating the mechanisms by which hyaluronan protects brain vascular endothelial cells from ferroptosis. The research addresses vascular contributions to cognitive impairment and dementia (VCID), the second leading...
- Federal Grant Award Summary The University of Virginia received a $689,148 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with a completion date of January 31, 2031. This five-year research initiative investigates the profibrotic effects of hematopoietic Y chromosome loss in heart failure with preserved ejection fraction (HFpEF). The research will explore the clinical, causal, and mechanistic relationships...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Maryland, Baltimore a $589,154 Project Grant effective February 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). The grant supports the development and validation of Normalized Cerebrovascular Reactivity (NCVR) magnetic resonance imaging technology to improve detection of vascular contributions to cognitive impairment in small-vessel disease (SVD) patients. The project...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Illinois a $2.55 million Project Grant under the Aging Research program (CFDA 93.866) on August 11, 2025, with a completion date of July 31, 2029. This research project investigates the mechanisms by which SARS-CoV-2 infection increases the risk of vascular contributions to cognitive impairment and dementia (VCID). The research will examine how COVID-19 weakens the blood-brain barrier (BBB) through...
- Federal Grant Award Summary Virginia Commonwealth University received a $552,883 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective January 1, 2026 through November 30, 2030. This award supports research investigating the selective vulnerability of cholinergic neurons in Alzheimer's disease, with particular focus on understanding how soluble oligomeric amyloid-beta 42 (oAβ42) interacts with α7β2-containing nicotinic acetylcholine receptors...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $2.2 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the five-year period from January 1, 2026 through December 31, 2030. The award supports research investigating mechanistic links between endothelial aging and dementia through development of a novel human induced pluripotent stem cell-endothelial cell (hiPSC-EC) model of aging. The research will...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $1,459,072 on August 1, 2025, under the Aging Research program (CFDA 93.866) to conduct research on Alzheimer's Disease (AD)-related neurological dysfunction. The research will deliver scientific knowledge and methodological innovations focused on understanding how inhibitory interneurons—specifically parvalbumin (PVALB) and somatostatin (SST) cell types—contribute...
- Federal Grant Award Summary The University of Virginia received a $1,044,334 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective August 1, 2025, through May 31, 2030, to conduct research on the mechanisms of ribosomal DNA (rDNA) instability during aging. The award supports investigation into how genomic instability contributes to the aging process through analysis of DNA double-strand breaks (DSBs), replication fork barriers, and the regulatory...
- Federal Project Grant Award Summary The National Institute on Aging (NIA), through its Aging Research program (CFDA 93.866), awarded $634,658 to the University of Colorado-Denver on February 15, 2026, with a project completion date of November 30, 2030. This Project Grant supports biomedical research investigating the interaction between systemic endothelial glycocalyx fragility and brain dysfunction in aged sepsis survivors. The research addresses a critical public health challenge, as sepsis...
The University of Virginia received a $2.88M Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded July 1, 2026, with a completion date of June 30, 2030. This award funds research investigating the role of microglia in neurovascular coupling and hypertensive cerebral small vessel disease (CSVD). The research will produce scientific knowledge and experimental findings regarding how microglial dysregulation affects cerebral blood flow (CBF) and cerebrovascular reactivity, utilizing advanced neuroimaging and molecular analysis techniques including laser speckle contrast imaging, magnetic resonance imaging-arterial spin labeling, functional ultrasound, and single-nucleus RNA sequencing. The project will deliver three primary research products: (1) empirical data on microglial regulation of cerebrovascular reactivity in grey and white matter using multiple imaging modalities; (2) transcriptomic analysis of microglial and endothelial cell changes under hypertension and cerebral hypoperfusion conditions; and (3) preclinical efficacy data on microglial repopulation or grafting as potential therapeutic interventions for hypertension-induced cognitive deficits and vascular dementia. The research outcomes are intended to elucidate mechanisms underlying vascular dementia pathology and identify potential therapeutic targets, with implications for understanding the intersection of vascular and Alzheimer's disease-related cognitive impairment.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.9m | 6/9/26 |