Project Grant R21AG094068
- Federal Project Grant Award Summary The Medical College of Wisconsin, Inc. received a $429,000 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 1, 2026, with completion by January 31, 2028. The research project investigates the role of chromosome 21 (HSA21) gene overexpression in aging-associated and amyloid-beta-induced neurodegeneration using Caenorhabditis elegans as a model organism. The primary deliverable is a systematic genetic...
- Federal Grant Award Summary The Medical College of Wisconsin, Inc. received a $312,000 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 1, 2025, through May 31, 2027. The research project investigates the functional role of late-onset Alzheimer's disease (LOAD)-associated genes in neurodegeneration and protein aggregation-induced neurotoxicity. Using Caenorhabditis elegans as a model organism, the research aims to...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded University of Wisconsin-Madison a $640,906 Project Grant effective June 1, 2025, through March 31, 2030, under the Aging Research program (CFDA 93.866). The project delivers advanced neuroimaging research and analysis services focused on elucidating cerebrovascular disease (CVD) pathways to cognitive decline. The primary products include the development and application of a suite of non-invasive vascular neuroimaging tools...
- Federal Project Grant Award Summary Rush University Medical Center received a $1.99 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to identify molecular mechanisms linking cerebrovascular disease (CVD) pathologies to Alzheimer's disease and Alzheimer's disease and related dementias (AD/ADRD) in older adults. Awarded on July 1, 2025, with completion anticipated by April 30, 2030, this research initiative addresses a critical gap...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Johns Hopkins University a $480,710 Project Grant effective September 5, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). The award supports scientific investigation into a novel vascular signaling pathway that regulates neuronal survival in neurodegenerative diseases, specifically Alzheimer's disease and related dementias (ADRD), amyotrophic lateral sclerosis (ALS), and...
- Federal Project Grant Award Summary Duke University's Office of Research Administration is executing a scientific research project funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The $715,801 project grant, awarded June 1, 2025, with completion scheduled for March 31, 2030, supports biomedical research investigating the mechanisms linking hypertension and aging to postoperative delirium and subsequent Alzheimer's disease and related dementias...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $445,130 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030. This research project focuses on elucidating the mechanisms by which Membrane Spanning 4A (MS4A) genes regulate neurodegeneration in Alzheimer's disease and related neurodegenerative disorders, including frontotemporal dementia,...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received $1,469,914 in project grant funding from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period January 1, 2026 through December 31, 2030. The award supports research titled "Probing Mechanistic Links Between Endothelial Aging and Dementia," which develops and applies a novel human induced pluripotent stem cell-endothelial cell (hiPSC-EC) model to investigate the...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant totaling $1,851,569 under the Aging Research program (CFDA 93.866) for the period June 1, 2025, through March 31, 2030. This research initiative, titled "First In Last Out: How Development Informs Neurodegeneration," investigates the biological mechanisms linking early brain development to late-life Alzheimer's disease (AD) pathology. The project aims to empirically...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Tufts University School of Medicine a $470,000 Project Grant under the Aging Research program (CFDA 93.866) on February 1, 2026, with a completion date of January 31, 2028. This grant funds research titled "Elucidating the Interplay Between AD Genetic Variants Using Human iPSC-Derived Brain Cells," which investigates the genetic mechanisms underlying Alzheimer's disease (AD). Given that AD has an estimated...
The National Institute on Aging awarded The Medical College of Wisconsin, Inc. a Project Grant totaling $441,460 under the Aging Research program (CFDA 93.866) for the period February 1, 2026 through January 31, 2028. This research initiative investigates the role of the adaptor protein P66SHC in cerebrovascular dysfunction associated with Alzheimer's disease and related dementias. The research aims to elucidate molecular mechanisms linking vascular impairment to cognitive decline by utilizing genetically modified rat models, specifically crossbreeding TGF344-AD rats (which exhibit age-dependent amyloid-beta 42 accumulation) with P66SHC knockout and constitutively active P66SHC mutant rats to evaluate cerebral vascular reactivity and cognitive function outcomes. The primary deliverables under this award include comparative analyses of cerebral vascular reactivity across genetically modified rat models with targeted SHC1 gene mutations, assessments of cognitive dysfunction progression in relation to vascular changes, and experimental data characterizing the functional significance of P66SHC signaling in Alzheimer's disease pathophysiology. These research outputs are intended to advance understanding of how vascular dysfunction contributes to age-related cognitive impairment and may identify therapeutic targets for mitigating cognitive decline in Alzheimer's disease.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $441.5k | 1/22/26 |