Project Grant R01AG092877
- Federal Project Grant Award Summary The University of California, San Diego received a $3.14 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 15, 2025, with completion targeted for August 31, 2029. This research initiative will deliver comprehensive scientific analysis of human brain neuropeptidomes and their biosynthetic proteases in normal aging and Alzheimer's disease (AD) conditions. The project will elucidate the...
- Federal Grant Award Summary The University of California, San Diego received a $439,750 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded May 15, 2026, with a completion date of April 30, 2027. This two-year research initiative aims to advance understanding of hippocampal neural coding mechanisms related to spatial navigation and cognitive function during aging and in Alzheimer's disease (AD) pathogenesis. The project addresses a...
- Grant Award Summary The University of California, San Diego received a Project Grant award of $127,224 from the National Institute on Aging under the Aging Research program (CFDA 93.866) to investigate the role of s-nitrosylated phospholipase D3 (SNO-PLD3) in Alzheimer's disease pathophysiology. The research project, which commenced on October 24, 2025 and will conclude on August 31, 2028, seeks to elucidate the mechanistic pathological importance of SNO-PLD3—a redox-mediated posttranslational...
- Federal Grant Award Summary The University of California, San Diego received a $150,512 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded August 2, 2026, with completion targeted for August 1, 2027. This award supports development of a novel diffusion Magnetic Resonance Imaging (MRI) signature for early detection of Alzheimer's Disease (AD). The project addresses a critical public health need, as AD remains the fifth leading cause of death...
- Federal Grant Award Summary The University of California, San Diego received a $165,488 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded March 1, 2026, with completion targeted for November 30, 2028. This project addresses high rates of Alzheimer's disease (AD) misdiagnosis, which currently occurs in up to 25% of cases and leads to inappropriate treatment in 18-67% of patients. The primary deliverables include construction of a...
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Regents of the University of California, San Francisco $681,908 under the Aging Research program (CFDA 93.866) on February 15, 2026, with a completion date of November 30, 2030. This project grant supports biomedical research directed at understanding protective mechanisms in tauopathies, a class of neurodegenerative diseases characterized by pathological tau protein aggregation, including Alzheimer's...
- Federal Grant Award Summary The University of California, San Diego received a $140,589 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded on March 17, 2026, with a completion date of February 28, 2027. This award supports research investigating the molecular mechanisms by which ketogenic metabolites ameliorate Alzheimer's disease (AD) pathology. The project focuses on dissecting how beta-hydroxybutyrate (BHB), the primary ketone body...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded University of California, Irvine $3.22M under the Aging Research program (CFDA 93.866) for a project grant commencing September 15, 2025, with completion scheduled for August 31, 2029. This project will deliver biomedical research services focused on understanding the role of the retrosplenial cortex in Alzheimer's disease (AD) pathogenesis. The research will establish the mechanisms by which neuronal hyperexcitability...
- Federal Project Grant Award Summary The University of California, San Diego received a $437,375 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through August 31, 2027. The award funds biomedical research investigating NEK7 (NIMA-related kinase-7) as a potential suppressor of inflammation in aging hearts through regulation of RNA-binding proteins. The research addresses the critical connection between...
The University of California, San Diego received a $674,455 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), with an award date of July 1, 2026 and completion date of March 31, 2031. This research project investigates the role of vascular sphingolipid metabolism in Alzheimer's disease pathogenesis. The grant supports biomedical research examining how cerebral blood vessel dysfunction contributes to disease progression, with particular focus on identifying alterations in lipid metabolic enzyme expression and sphingolipid composition in brain microvessels of Alzheimer's disease patients compared to age- and sex-matched controls. The research deliverables include mechanistic studies utilizing mass spectrometry-based proteomics and lipidomics analyses, development of endothelial-specific genetic models (specifically an endothelial-specific knockout of the ceramide synthesis enzyme SPTLC1), and experimental validation of how sphingolipid metabolism regulates brain vascular function and affects Alzheimer's disease progression. The findings are expected to advance understanding of vascular contributions to neurodegeneration and potentially identify new therapeutic targets for intervention in this age-related neurodegenerative disease.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $674.5k | 6/15/26 |