Project Grant RF1AG096215
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support a $185,074 research study conducted by the University of California, Berkeley. The goal of the study is to examine how brain network connectivity is associated with Alzheimer's disease (AD) risk, longitudinal pathology accumulation, and aging. The researchers will use positron emission tomography (PET) imaging and resting-state functional MRI (rs-fMRI) to investigate the mechanisms of how...
- This Project Grant award of $1,851,569 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research investigating the relationship between early brain development and later neurodegeneration associated with Alzheimer's disease (AD). The research aims to test two key hypotheses: 1) brain regions with high plasticity in early life are more susceptible to pathological changes later in life, and 2) the detrimental impact of social determinants of health (e.g., low...
- This $1,554,682 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund the development of three new multi-modal atlases based on high-resolution Human Connectome Project (HCP) data. The objectives are to: 1) Create a new data-driven atlas of spatially overlapping weighted grey-matter functional networks, 2) Develop a new atlas of white matter tracts and their corresponding grey matter projection territories, and 3) Complete a semi-automated...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $300,892 project grant to Duke University to conduct research on high-resolution diffusion imaging of brain connectivity in healthy aging and Alzheimer's disease. The project aims to examine how white matter disconnection affects brain function in both healthy aging and Alzheimer's disease, leveraging a high-resolution multi-shot diffusion-weighted imaging (DWI) protocol. The research...
- This federal Project Grant award for $2,557,260 from the National Institute on Aging (CFDA 93.866 Aging Research program) will fund a study titled "Lifecourse Predictors and Mechanisms of Early Clinical ADRD among Black and White Adults in their Sixties". The study aims to investigate the transition from midlife to early late-life and identify the earliest manifestations of Alzheimer's disease (AD) and Alzheimer's disease-related disorders (ADRD) in a diverse population. The research...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Southern California provides $622,401 over 5 years starting January 1, 2025 to research causal models of brain biomarker changes leading to Alzheimer's disease and related dementias (ADRD). The project aims to: 1) fit novel deep learning models to predict ADRD pathology from diffusion MRI data, 2) generate individualized brain morphology prediction maps as "digital...
- The Project Grant titled "The Role of Neighborhood Social Exposome Dynamics in Risk and Resilience to Alzheimer's Disease and Related Dementias" was awarded by the National Institute on Aging (NIA), under CFDA Program 93.866 - Aging Research. The $3,039,714 grant, with a performance period from September 15, 2025 to September 14, 2029, will investigate the pathways between 30 years of neighborhood-level social exposome change, individual modifiable Alzheimer's disease and related...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $791,086 aims to develop computational models that can predict the presence of non-Alzheimer's disease neuropathological changes, such as Lewy body disease, TDP-43 proteinopathy, and cerebral amyloid angiopathy, in individuals with Alzheimer's disease neuropathological changes. The project will leverage data from autopsy-confirmed datasets, in vivo neuroimaging, and clinical assessments to build...
- This $287,118 Project Grant was awarded on September 1, 2023 by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) grant program. The grant will fund the development of techniques to use deep transfer learning and multimodal data, including brain MRIs, genetic information, and cognitive tests, to enable the early detection and forecasting of Alzheimer's disease progression. The University of Massachusetts (UMass), as the prime awardee, will create an end-to-end...
- This federal Project Grant award for $528,876, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research to investigate the cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease (AD) and AD-related dementias (ADRD). The key goals of the project are to: Estimate genome-wide cis- and trans-acting quantitative trait loci (QTLs) effects for transcriptome-wide genes and proteome-wide proteins across 4 brain...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,001,700.00 to the University of Pittsburgh to investigate risk factors and consequences of white matter injury in brain regions affected by Alzheimer's disease (AD) pathology. The research will leverage neuroimaging and neuropsychological data to: (A) directly associate unhealthy white matter connectivity (UWMC) in AD-affected regions with co-localized AD pathology; (B) examine how UWMC interacts with AD pathology to influence cognition; and (C) assess associations between UWMC and early-/mid-life social determinants of health. The long-term goal is to characterize white matter injury in AD in order to inform refinement of disease-modifying therapies and preventive efforts. The award period runs from September 15, 2025 to August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 9/10/25 |