Project Grant R03AG100774
- Federal Project Grant Award Summary The University of Wisconsin-Milwaukee received a $293,454 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded January 15, 2026, with a completion date of December 31, 2030. The grant funds a research project investigating the neural basis of memory generalization and integration across the lifespan. The primary deliverable is empirical research employing functional magnetic resonance imaging (fMRI)...
- Federal Project Grant Award Summary Northwestern University's Sponsored Research Division received $148,050 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to conduct a research project investigating sex-specific hypothalamic pathology and immune infiltration in Alzheimer's disease (AD). The award, issued on September 27, 2025, with a completion date of May 31, 2028, funds biomedical research directed toward understanding the mechanisms underlying sex...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $1,366,056 Project Grant to Washington University, effective January 1, 2026 through December 31, 2030, under the Aging Research program (CFDA 93.866). The grant funds development of an innovative biocompatible fiber implant designed to enable long-term, multifunctional deep-brain imaging and manipulation in mouse models of Alzheimer disease. The implant integrates photoacoustic microscopy (PAM) and two-photon...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Southern California a $4.055 million Project Grant on September 15, 2025, to investigate the impact of circulating endocrine-disrupting toxicants on cognition, brain activity, and Alzheimer's disease (AD) biomarkers across the menopausal transition. This research, supported through the Aging Research program (CFDA 93.866), will leverage advanced toxicological and steroid hormone assay techniques to...
- Federal Grant Award Summary The Medical College of Wisconsin, Inc. received a $441,460 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for the period February 1, 2026 through January 31, 2028. The award supports research investigating the role of the adaptor protein P66SHC in cerebrovascular dysfunction associated with Alzheimer's disease (AD) and related dementias. The research project will generate scientific knowledge regarding molecular...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Washington a Project Grant of $3.08 million under the Aging Research program (CFDA 93.866) beginning September 1, 2025, and concluding August 31, 2029. This grant supports the development of statistical machine learning methods to create connectome-based biomarkers for the early detection of Alzheimer's disease and related dementias (ADRD). The project addresses a critical gap in current diagnostic...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of South Florida $3.297 million under the Aging Research program (CFDA 93.866) for a four-year project period (September 1, 2025 – August 31, 2029) to develop novel peptidomimetic biomaterials that inhibit amyloid-beta (Aβ42) aggregation in Alzheimer's disease. The research deliverables include the rational design and characterization of structurally related analogues to a lead compound that stabilizes Aβ...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $1,459,072 on August 1, 2025, under the Aging Research program (CFDA 93.866) to conduct research on Alzheimer's Disease (AD)-related neurological dysfunction. The research will deliver scientific knowledge and methodological innovations focused on understanding how inhibitory interneurons—specifically parvalbumin (PVALB) and somatostatin (SST) cell types—contribute...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $244,086 to the University of Wisconsin-Madison on June 13, 2025, under the Aging Research program (CFDA 93.866) to support a multimodal examination of Alzheimer's disease pathology and synaptic loss through January 31, 2027. This F31 predoctoral fellowship grant funds research designed to address the gap in measuring amyloid-beta and tau pathology accumulation and associated synaptic loss in living humans across...
- Federal Project Grant Award Summary The University of Florida's Division of Sponsored Research received a $2.33 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2029. The award funds research evaluating neuroimmune mechanisms and therapeutic targeting potential of the luteinizing hormone/chorionic gonadotropin (LH/CG) receptor in menopausal and Alzheimer's disease-affected brains....
Marquette University received a $309,000 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded May 15, 2026, with a completion date of April 30, 2028. The project conducts longitudinal imaging research in a transgenic rat model of Alzheimer's disease to identify early biomarkers of cognitive decline, with particular focus on how ovarian hormone loss interacts with Alzheimer's disease pathology to accelerate neural dysfunction and cognitive impairment in women during perimenopause. The research employs in vivo calcium imaging of prefrontal cortical neuronal ensembles, two-photon imaging of amyloid-beta deposits, and machine learning analysis to track changes in genetically defined excitatory and inhibitory neurons during working memory testing at multiple disease pathology timepoints. The project deliverables include identification of neuronal activity patterns predictive of future cognitive decline in both male and naturally cycling female subjects, determination of how hormone loss timing relative to amyloid deposition affects prefrontal cortex working memory encoding, and development of quantifiable neural biomarkers that correlate with behavioral deficits. By integrating advanced neuroimaging techniques with multilevel mixed effects statistical models, the research aims to close a fundamental knowledge gap regarding hormone-pathology interactions underlying cognitive decline, with direct application to developing interventional strategies for middle-aged women at heightened dementia risk.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $309.0k | 5/19/26 |