Project Grant R01AG092894

The National Institute on Aging awarded $768,024 to the University of Wisconsin System (University of Wisconsin – Madison) on September 1, 2026, under the Aging Research program (CFDA 93.866) to fund a project grant studying psychosocial, behavioral, and neuropsychological responses to learning amyloid and tau biomarker results in cognitively unimpaired or mildly impaired adults at risk for Alzheimer's disease.

The project will enroll 240 participants (including 25 percent Black/African American or Native American individuals) already enrolled in observational studies and disclose their amyloid positron-emission tomography (PET) and tau PET results to them. The research will measure psychosocial and behavioral outcomes at baseline and up to 18 months after disclosure, and neuropsychological outcomes at baseline and up to 24 months after disclosure, to evaluate longitudinal trajectories across three specific aims: determining associations between learning biomarker profile and psychosocial (primary) and behavioral (secondary) outcomes; testing associations with subjective and objective memory ratings and performance; and testing whether illness perceptions and health beliefs about dementia risk mediate relationships between biomarker profile and outcomes. The project will test the hypothesis that learning amyloid-positive/tau-positive results associates with greater psychosocial and behavioral impacts than amyloid-positive/tau-negative or amyloid-negative/tau-negative results.

Work is performed in Madison, Wisconsin. The period of performance runs from September 1, 2026, through April 30, 2031.