Project Grant R01AG094088
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $2.003 million Project Grant to the University of Pittsburgh under the Aging Research program (CFDA 93.866) on September 15, 2025, with a completion date of August 31, 2029. This award funds research to characterize white matter injury in Alzheimer's disease (AD) and its role in cognitive decline. The study employs a novel, spatially precise neuroimaging methodology called Unhealthy White Matter Connectivity (UWMC) to...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $674,455 Project Grant to the University of California, San Diego (UCSD) effective July 1, 2026, through March 31, 2031, under the Aging Research program (CFDA 93.866). This award funds research investigating the role of vascular sphingolipid metabolism in Alzheimer's disease pathology. The project delivers advanced scientific research services, including mass spectrometry-based proteomics and lipidomics analysis to...
- Federal Grant Award Summary The University of Arizona received a $3.03 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on September 30, 2025, with a completion date of September 29, 2029. Led by Principal Investigator Dr. Grilli, this research initiative focuses on developing and validating novel semantic memory assessment measures to detect early Alzheimer's disease (AD) pathology in cognitively unimpaired and mildly...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Johns Hopkins University a Project Grant of $954,302 on September 5, 2025, under the Aging Research program (CFDA 93.866) to investigate a novel vascular pathway regulating neuronal survival in neurodegenerative diseases. The research project, which extends through May 31, 2030, focuses on characterizing the role of glycerophosphodiester phosphodiesterase 2 (GDE2), a vascular endothelial cell enzyme that cleaves...
- Federal Grant Award Summary The University of Virginia received a $2.88 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective July 1, 2026, through June 30, 2030. This four-year research award supports investigation into the role of microglia in neurovascular coupling and hypertensive cerebral small vessel disease (CSVD). The project deliverables consist of three coordinated research aims employing advanced neuroimaging techniques,...
- Federal Project Grant Award Summary The University of Arizona received a $102,368 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded June 15, 2026, with completion targeted for May 31, 2028. This research initiative aims to develop and evaluate therapeutic approaches targeting the brain's lymphatic system to treat Alzheimer's disease (AD) and...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $589,154 Project Grant to the University of Maryland, Baltimore, effective February 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). The project, titled "Normalized Cerebrovascular Reactivity MRI in Small-Vessel-Disease (SVD) Related Cognitive Impairment," will develop and validate an advanced magnetic resonance imaging (MRI) technique to improve detection of cerebrovascular...
- Federal Grant Award Summary The National Institute on Aging awarded the University of South Florida a $3.33 million Project Grant on September 22, 2025, under the Aging Research program (CFDA 93.866) to conduct transcriptome-wide mapping of the brain N6-methyladenosine (M6A) methylome in Alzheimer's disease through May 31, 2030. The project will deliver three primary outputs: (1) the first high-resolution reference map of brain M6A methylation sites in older adults' brains; (2) identification of...
- Federal Grant Award Summary The National Institute on Aging awarded a $656,829 Project Grant to the University of Rochester effective January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the selective vulnerability of the fronto-insular network (FIN) in aging and Alzheimer's disease (AD). The five-year research initiative, concluding December 31, 2030, combines in vivo structural, functional, and molecular analyses with behavioral assessments in mouse models to...
- Federal Project Grant Summary The National Institute on Aging (NIA) awarded a $5.06 million Project Grant to the University of Alabama at Birmingham (UAB) on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine the impact of undiagnosed Alzheimer's disease and related dementias (ADRD) on healthcare utilization across geographic regions. The project, which extends through September 14, 2029, will produce a uniquely integrated dataset combining Medicare claims data with...
The National Institute on Aging (NIA) awarded the University of Arizona a $996,193 Project Grant on July 15, 2026, under the Aging Research program (CFDA 93.866) to evaluate the interaction and time course of small and large vessel cerebrovascular disease contributions to Alzheimer's disease risk (ADRD). The research will examine how extracranial large vessels (carotid and vertebral arteries), intracranial large vessels (middle, anterior, and posterior cerebral arteries), and cerebral small vessels interact over time to influence ADRD outcomes, with particular attention to differential effects between males and females. The project will analyze preliminary findings suggesting additive or synergistic effects of small and large vessel diseases and will evaluate whether carotid endarterectomy treatment affects cerebrovascular pathways, including white matter lesion accumulation, cerebral perfusion, and inflammation parameters. The five-year project, extending through June 30, 2031, aims to identify specific cerebrovascular disease patterns and pathways associated with ADRD outcomes, their underlying mechanisms, and potential treatments that could impact both large and small vessel disease parameters. Deliverables will include research findings on cerebral hypoperfusion as a fundamental pathology contributing to ADRD-associated hallmarks such as neurofibrillary tangles and beta-amyloid accumulation, as well as longitudinal data examining treatment effects over a two-year intervention period. This research directly supports NIA's mission to advance understanding of aging processes and prevention and treatment strategies for Alzheimer's disease and related dementias.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $996.2k | 7/7/26 |