Project Grant R01AG096741
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of Missouri System $676,608 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of the gut-brain axis in Alzheimer's disease mitigation through a translational study combining human and preclinical animal experiments. The project examines how dysbiosis—microbial imbalance—correlates with Alzheimer's disease biomarkers (amyloid plaques, tau...
- The National Institute on Aging awarded the University of Wisconsin-Madison $427,625 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate cerebral small vessel disease pathways in vascular contributions to cognitive impairment and dementia and Alzheimer's disease using ferumoxytol-enhanced MRI. The research will employ novel microvascular biomarkers including quantitative characterization of vascular density and hemodynamic measures of microvascular pulsatility...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $441,460 to The Medical College of Wisconsin, Inc. on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate P66SHC signaling in cerebrovascular impairment associated with Alzheimer's disease. The award funds research testing the hypothesis that adaptor protein P66SHC signaling contributes to cognitive deficiencies and loss of cerebral vascular...
- The National Institute on Aging awarded Marquette University $309,000 on May 15, 2026, under the Aging Research program (CFDA 93.866) to conduct longitudinal imaging studies in a preclinical Alzheimer's disease model aimed at identifying early biomarkers of cognitive decline. The project uses in vivo calcium imaging of prefrontal cortical neuronal ensembles and two-photon imaging of amyloid-beta deposits in a transgenic rat model to track changes in genetically defined excitatory and...
- Federal Project Grant Award Summary The Medical College of Wisconsin, Inc. received a $312,000 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 1, 2025 through May 31, 2027. This award supports research investigating the functional role of late-onset Alzheimer's disease (LOAD)-associated genetic variants in neurodegeneration and protein aggregation-induced neurotoxicity. The project utilizes Caenorhabditis elegans (C....
- The National Institute on Aging awarded New York University $712,578 on February 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a prospective study identifying viral infections associated with cognition decline and Alzheimer's disease risk across three prospective cohorts. The award supports comprehensive serologic profiling using VirScan, a bacteriophage immunoprecipitation sequencing technology, to detect immune responses to human viruses and analyze antiviral antibodies in...
- The National Institute on Aging awarded the University of Wisconsin - Madison $646,358 on June 15, 2026, under the Aging Research program (CFDA 93.866) to conduct an observational study characterizing oral hypofunction, dysphagia, and airway microbiome profiles in older adults presenting to emergency departments with pneumonia. The research involves comprehensive assessments of oral and swallowing function combined with metagenomic analyses and application of saliva samples to a...
- The National Institute on Aging awarded Brigham & Womens Hospital Inc. $135,540 under Project Grant K99AG097920 on July 1, 2026, to investigate microbial aging dynamics in cognitive health through a multi-omics approach. The award falls under the Aging Research program (CFDA 93.866), which supports biomedical, social, and behavioral research directed toward understanding the aging process and Alzheimer's disease and related dementias. The research integrates multi-omics analysis to examine...
- The National Institute on Aging awarded $427,625 to The Washington University on September 1, 2026, under the Aging Research program (CFDA 93.866) to probe cerebellar cortex computations in Alzheimer's disease. The work examines cerebellar nodulus and uvula function in two Alzheimer's disease mouse models—APP/PS1 and 3XTG-AD—at 3, 6, and 12 months of disease progression to assess how hallmarks of Alzheimer's disease contribute to cerebellar dysfunction. The project tests the hypothesis that...
- The University of South Florida received a $3,385,215 Project Grant award from the National Institute on Aging, part of the National Institutes of Health within the Department of Health and Human Services. The grant was awarded under the Aging Research program (CFDA 93.866) to fund research titled "Microbial Therapy Improves Gut Permeability to Reduce Cognitive Decline and Alzheimer's Disease." The grant will support research from August 2021 through July 2024 to study the impact of...
The National Institute on Aging awarded The Medical College of Wisconsin, Inc. $645,037 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate microbial and neurovascular predictors for subtypes of prodromal Alzheimer's disease. The project examines the interactions between gut microbiota, neurovascular dysfunction, Alzheimer's disease biomarkers, and clinical progression in prodromal AD. The research tests the hypothesis that microbial agents—bacteria, viruses, and associated metabolites—exacerbate neurovascular dysfunction and cognitive decline in prodromal AD. Prior pilot work identified discriminatory bacterial strains including oral pathogens capable of modifying bile acids, bacteriophages associated with bile acid-modifying bacteria and immunity-affecting phages, and negative associations between inflammation-inducing bacteria and cognitive functioning. The project will systematically explore the gut-neurovascular axis in human subjects to advance understanding of early cognitive decline and progression from prodromal to dementia stages. The performance period runs from September 1, 2026, through May 31, 2031, with work performed in Wauwatosa, Wisconsin. The assistance type is a project grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $645.0k | 8/18/26 |