Project Grant R21AG098707
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $427,625 to The Washington University Office of Sponsored Research Services, effective February 15, 2026, through January 31, 2028, under the Aging Research program (CFDA 93.866). This research initiative addresses intramuscular adipose tissue (IMAT) quality in aging populations through a dual-track investigative approach combining human clinical studies and mouse model research. The project delivers...
- Federal Project Grant Award Summary The National Institute on Aging awarded a $698,690 Project Grant to the University of Wisconsin–Madison (effective February 1, 2026, through January 31, 2031) under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms of fiber type-specific skeletal muscle dysfunction with aging. The research addresses a significant health care problem: age-related loss of muscle mass and power-generating capacity (sarcopenia and dynapenia) that...
- Federal Project Grant Award Summary Panorama Research Incorporated received a $354,000 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on September 20, 2025, with an ultimate completion date of September 19, 2026. The grant funds the development of a novel therapeutic approach to address sarcopenia—the age-related loss of skeletal muscle mass, quality, and strength—which affects a significant portion of the elderly population, particularly those...
- Federal Project Grant Award Summary San Jose State University Research Foundation received a $183,125 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025 through July 31, 2029. The award funds fundamental biomedical research investigating the mechanisms by which diet regulates muscle stem cell (MUSC) activation and proliferation in Drosophila models. The research...
- Federal Grant Award Summary The National Institute on Aging awarded University of Massachusetts Medical School a Project Grant of $452,783 under the Aging Research program (CFDA 93.866) to conduct biomedical research on molecular mechanisms of neuronal cell death and neurodegeneration. The award period runs from June 1, 2026, through May 31, 2028. The project delivers research services focused on understanding how to protect the brain from Alzheimer's disease by investigating the relationship...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- Federal Grant Award Summary The University of Florida Division of Sponsored Research received a $103,969 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective July 3, 2026, with a completion date of June 30, 2028. The award supports research investigating circadian epigenetic regulation of aging skeletal muscle and the impact of exercise on muscle maintenance. The research will generate comprehensive genome-wide, circadian...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $456,703 Project Grant to the University of Massachusetts Medical School (UMMS) under the Aging Research program (CFDA 93.866), effective July 1, 2026, through June 30, 2028. This award funds biomedical research investigating the neuronal mechanisms that direct stress-responsive transcriptional programs in response to oxidative stress. The research deliverables include identification of oxidative stress response...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant totaling $450,200 to The Trustees of Columbia University in the City of New York (Health Sciences Division) on May 15, 2026, under the Aging Research program (CFDA 93.866). This exploratory R21 grant funds a systematic investigation into age-dependent changes in primary sensory neurons, with completion scheduled for April 30, 2028. The research delivers a cell-type-resolved map of how normal aging...
- Federal Grant Award Summary Boston University Medical Campus received a $686,700 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded August 15, 2025, with completion by July 31, 2027. This grant supports a two-phase research initiative investigating chronic wound stress as a catalyst for systemic aging and functional decline. The project will establish and validate a mouse model simulating chronic wound stress across different adult...
The Buck Institute for Research on Aging received a $533,500 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded July 15, 2026, with completion targeted for June 30, 2028. This award supports research investigating the role of autonomic nervous system (ANS) innervation in muscle stem cell (MuSC) aging and its relationship to sarcopenia—age-related loss of skeletal muscle mass and function affecting 10-22% of the global adult population. The research directly addresses a critical clinical gap, as current interventions (exercise and nutrition) have failed to increase muscle mass despite improving strength, and no approved pharmacological treatments exist for sarcopenia. The project will employ a novel Drosophila melanogaster model to examine the functional link between ANS neurons and MuSCs, building on preliminary evidence demonstrating direct innervation of MuSCs by autonomic neuron axons in adult fly muscles. Research deliverables include refined whole-body imaging methods and genetic tools for robust labeling of both the ANS and MuSCs, characterization of age-related changes in MuSC counts and spatial distribution, and identification of mechanisms by which ANS innervation regulates MuSC biology. By elucidating this previously understudied regulatory pathway, the research aims to identify druggable targets for improving muscle healthspan in aging populations—a critical advancement given sarcopenia's significant impact on mortality, hospitalization, and quality of life in elderly populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $533.5k | 7/14/26 |