Project Grant R21AG095939
- This federal Project Grant award for $1,249,147.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant is a collaborative effort between Epicypher, Inc., a biotechnology company in Durham, North Carolina, and Dr. Nicolas Young of Baylor College of Medicine to develop a novel platform called AgingPTM for studying aging-associated combinatorial histone post-translational modifications (ACPTMs) in tissue. This platform is intended to...
- This federal Project Grant award of $291,913 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to Virscio, Inc., a for-profit research company located in Connecticut. The award is focused on developing epigenetic and senescent biomarkers using non-human primate tissues to advance the understanding of biological aging processes and potential anti-aging strategies. The project aims to create minimally invasive biomarker tools, such as blood and skin-based assays,...
- The National Institute on Aging (CFDA 93.866 Aging Research) awarded a $506,000 Project Grant to the Scripps Research Institute to engineer a novel biomolecular condensate (BMC)-based tool with tunable physicochemical properties. The goal is to create an orthogonal selective autophagy receptor (SAR)-like BMC capable of supporting autophagosome biogenesis and selective cargo recruitment. This will enable detailed investigation of the biophysical regulatory mechanisms of BMCs in autophagy, which...
- The National Institute on Aging (NIA) awarded a $397,902 Project Grant to Panluminate Inc., a woman-owned small business in Connecticut, to develop FLASH-PULSE, an automated and multiplexed imaging solution for rapidly mapping the distribution of specific cell markers within tissue samples at the subcellular scale. The project aims to create a microfluidics-based system and novel probes to enable 32-plex protein imaging of formalin-fixed paraffin-embedded (FFPE) tissue samples without the need...
- This federal Project Grant award of $3,101,237.00 was provided by the National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, under the Aging Research federal grant program (CFDA 93.866). The funding supports a research project investigating the mechanisms linking persistent DNA damage to immune responses and hematopoietic stem and progenitor cell function in the context of aging and DNA repair deficiency. Key objectives of the project include: 1) elucidating...
- This federal Project Grant award of $438,625.00 from the National Institute on Aging (CFDA 93.866 Aging Research) to Brown University aims to study how the cellular senescence phenotype changes over time and develop technology to track the duration of cells in senescent states. The key objectives are to (1) examine how the senescence phenotype, including the senescence-associated secretory phenotype (SASP), evolves from early to deeper states, and (2) advance a multi-symbol molecular recorder...
- This federal Project Grant award of $190,278.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the role of transposable elements in septic immune aging. The research aims to 1) examine the dynamics of transposable element de-repression as a function of age and sepsis, and 2) employ machine learning to quantify immune aging and identify specific transposable elements...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $320,511 project grant to TRU Diagnostics Inc. to develop a novel diagnostic tool for chronic diseases. The project aims to create a "non-stochastic W function epigenomic roadmap" using systems-based dynamic modeling to capture the shifting homeostatic set points of epigenetic markers over time. This transformative approach aims to enable personalized, dynamic health forecasts...
- This federal Project Grant award of $240,069 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University will be used to explore the effects of lifestyle on immune system activity and molecular markers of aging across populations with diverse lifestyles, from traditional subsistence-level to highly urban. The research will focus on analyzing three age-associated molecular phenotypes - gene expression, DNA methylation, and telomere length - in peripheral blood...
- This Project Grant award, valued at $647,866.00 and provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research to investigate the epigenetic regulation of nuclear cGAS activity and its role in aging-related inflammation. The key objective is to understand how aging-related changes in histone acetylation patterns and associated chromatin-binding proteins, such as BRD4, activate the innate immune sensor cGAS and contribute to chronic...
This federal Project Grant award of $498,366.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop a platform for high-resolution imaging of peripheral blood mononuclear cells (PBMCs) in arrays of microscopic conical wells to assess biological age. The project, led by the University of California, San Diego, seeks to effectively implement an imaging-based chromatin and epigenetic age (IMAGE) analysis approach that captures changes in chromatin organization and epigenetic marks correlated with biological age. This platform will enable the capture, immuno-labeling, and imaging of PBMCs from fingerstick blood samples to quantify epigenetic signatures associated with aging, addressing the challenge of obtaining small cell samples for IMAGE measurements. The award period runs from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $498.4k | 8/26/25 |