Project Grant R21AG094050
- Federal Grant Award Summary The University of Florida Division of Sponsored Research received a $419,375 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 1, 2025, through May 31, 2026. The award supports research investigating the pathological implications of tau-ribonucleic acid (RNA) interactions in tauopathies, particularly Alzheimer's disease (AD). The project aims to identify and characterize RNA motifs that bind...
- Federal Project Grant Award Summary The University of Florida, Division of Sponsored Research, received a $507,371 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective June 1, 2025, through March 31, 2030. This award funds research investigating the roles of CASP8 SVA GGGAGA repeat expansions in Alzheimer's Disease (AD). The project will deliver scientific research products examining microsatellite repeat expansions as potential genetic...
- Federal Project Grant Award Summary The University of Florida, Division of Sponsored Research, received a $126,640 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, with a completion date of May 31, 2030. This research initiative delivers a comprehensive scientific investigation aimed at identifying an optimal and robust measure of allostatic load (AL)—a physiological indicator of cumulative wear and tear—and...
- Federal Project Grant Award Summary The University of South Florida received a $1.70 million project grant awarded September 22, 2025, by the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct transcriptome-wide mapping of the brain M6A methylome in Alzheimer's disease. The award, extending through May 31, 2030, supports comprehensive research utilizing novel technologies for N6-methyladenosine (M6A) profiling at base-resolution to create the first...
- Federal Grant Award Summary The University of Florida Division of Sponsored Research received a $2.33 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 1, 2025, through August 31, 2029. This award supports a four-year research initiative investigating the neuroimmune mechanisms of the luteinizing hormone/choriogonadotropin (LH/CG) receptor as a therapeutic target for cognitive decline associated with menopause and...
- Federal Grant Award Summary The University of South Florida received a $3.3 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 1, 2025 through August 31, 2029. This award supports the development of novel peptidomimetic biomaterials designed to inhibit amyloid-beta (Aβ42) aggregation as a therapeutic intervention for Alzheimer's disease. The primary deliverables include the rational design and synthesis of structurally...
- Federal Grant Award Summary The University of Florida received a $298,296 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 9, 2025, with completion scheduled for May 31, 2030. This K02 award supports a five-year comprehensive leadership development program designed to advance the principal investigator's transition from early-career independence to a mid-career researcher leading multiple federally-funded research...
- Federal Project Grant Award Summary The University of South Florida received a $412,500 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded June 1, 2025, with a completion date of May 31, 2027. This award funds a comprehensive research initiative to identify novel biomarkers for early diagnosis and prognosis prediction of Alzheimer's disease (AD) through investigation of brain extracellular matrix (ECM) composition changes during normal...
- The University of Florida was awarded a $3.86 million Project Grant from the National Institute on Aging, part of the National Institutes of Health within the Department of Health and Human Services. The grant falls under the Aging Research program (CFDA 93.866), which supports biomedical, social and behavioral research on aging. The three-year grant will fund research to test the hypothesis that novel types of repeat-associated non-AUG (RAN) proteins contribute to amyotrophic lateral...
- Federal Project Grant Award Summary Duke University's Office of Research Administration was awarded $509,413 by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) on September 15, 2025, for a project period extending through May 31, 2030. The award supports scientific research investigating epitranscriptomic regulation of microglia in Alzheimer's disease (AD), specifically examining how m6A (N6-methyladenosine) modifications of messenger RNA control microglial...
The University of Florida received a $507,214 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 15, 2026, through January 31, 2028. This exploratory/developmental R21 grant funds systematic investigation into the regulation and function of long-noncoding RNA SLAMR (Suppressor of LARP6-Associated MCRNA Remodeling) in Alzheimer's disease (AD) pathogenesis. The research will assess how SLAMR modulates translation and structural synaptic plasticity in both APP knock-in (APP NL-G-F) and tau (PS19) mouse models of AD, building on preliminary findings demonstrating that SLAMR expression is impaired in AD models and that SLAMR gain-of-function enhances translation and synaptic function. The grant deliverables include systematic functional experiments designed to elucidate the role of SLAMR-mediated translation in AD progression, with anticipated outcomes that will advance understanding of long-noncoding RNAs in AD pathogenesis and inform the development of long-noncoding RNA-based therapeutics. Research will be conducted at the University of Florida's Jupiter, Florida facility under the Division of Sponsored Research, with results expected to influence translational approaches to treating age-related neurodegenerative disease.Summary of Federal Project Grant Award
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $507.2k | 2/6/26 |