This federal Project Grant award from the National Institute on Aging (NIA) under CFDA Program 93.866 "Aging Research" provides $1,306,404 to The Winifred Masterson Burke Medical Research Institute, Inc. to conduct research aimed at understanding the mechanisms underlying neuronal hyperexcitability in the entorhinal cortex due to Alzheimer's disease pathology.
Specifically, the research project will investigate the role of excitatory and inhibitory neurons in the entorhinal cortex of mouse models of Alzheimer's disease, using advanced techniques such as optogenetics, chemogenetics, and large-scale electrophysiological recordings. The goals are to identify which neuron types are most vulnerable to Alzheimer's pathology, and to test whether modulating their activity can restore function and reverse behavioral deficits. The findings from this innovative, interdisciplinary study could inform the development of better diagnostic tools and therapeutic approaches for Alzheimer's disease.
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