Project Grant R21AG088613

Award Date 9/15/24
Completion Date 8/31/26
Dollars Obligated $418K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Kalamazoo, MI 49008, USA
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This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research supports a research study to determine how biological sex influences the self-renewal of B1 cells, a subset of B cells that produce natural antibodies, in aged mice and humans. The goal is to elucidate the mechanisms behind differential B1 cell self-renewal in aged males versus aged females, which could inform strategies to maintain healthy natural immunity into old age. The $1,526,780 award,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop and evaluate immunocytokines for sustained delivery of macrophage colony-stimulating factor (M-CSF) to selectively activate parenchymal border macrophages (PBMs) in the brain. The $234,000 award to the Regents of the University of Michigan will support proof-of-concept studies to improve cerebrospinal fluid dynamics and treat aging- and Alzheimer's disease-associated deficits. The key...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $696,896 to the University of Texas Health Science Center at Houston to conduct research on the impact of the gut microbiome on B cell-mediated neuroinflammation in cerebral amyloid angiopathy (CAA). The research aims to investigate three key hypotheses: (1) CAA induces B cell-driven inflammation in the brain; (2) CAA-induced gut dysbiosis can promote B cell-mediated neuroinflammation...
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