This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $454,024 aims to investigate high-frequency oscillations (HFOs) as a potential new biomarker for Alzheimer's disease. The research will be conducted by the Research Foundation For Mental Hygiene, Inc. at the Nathan S Kline Institute. The primary goals are: (1) to determine if HFOs originate in the hippocampus and spread to other brain regions as Alzheimer's progresses, (2) to manipulate HFOs in real-time to evaluate effects on memory, and (3) to test a gene therapy approach for reducing HFOs and improving memory in an Alzheimer's mouse model. The award will leverage flexible electrode arrays and closed-loop protocols to longitudinally assess HFOs and their relationship to other Alzheimer's-related EEG abnormalities. The findings are expected to provide an improved understanding of HFOs as a biomarker and novel strategies for modulating them to potentially benefit memory and other Alzheimer's symptoms.
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