Regulation of mechanical coupling in aging myocardium
Active Project Grant Awarded Last action
- Award ID
- R21AG077036
- Recipient
-
Lankenau Institute For Medical Research UEI X7Y6RNVA4NR6
- Awarding agency
-
National Institute on Aging
National Institutes of Health, Department of Health and Human Services
- Obligated
- $770,588
Award facts
- Assistance listing
- 93.866 Aging Research
- Completion date 81% complete
- Originally
- Place of performance
- Wynnewood, PA 19096, USA
Award details come from USAspending.gov.
Description
- Abstract
- Age modifies heart structure and function, even in the absence of overt cardiovascular disease. With age-related cardiac remodeling, the heart undergoes extensive cellular and molecular changes that result in a stiffer less compliant heart that experiences an overall decline in function. Yet, the human heart is capable of functioning for decades despite minimal cell turnover or regeneration, suggesting that some mechanisms of age-related cardiac remodeling may be compensatory and beneficial, helping sustain heart function over our life span. Recent evidence indicates the upregulation of cytoskeletal proteins may represent a cardioprotective mechanism in the aging heart. In this exploratory R21 proposal, we hypothesize that enhancing the cytoskeletal connection between N-cadherin and the cortical actin network represents an essential compensatory mechanism to maintain force transmission in the aging mammalian heart. To test this hypothesis, the regulation of vinculin, a force-sensitive cytoskeletal protein, will be investigated during cardiac aging in mice. The following interrelated aims are proposed: (1) to test the hypothesis that ABL kinase is required to maintain mechano- electrical integrity in the aging heart. (2) to test the hypothesis that inhibition of tyrosine phosphorylation of vinculin will perturb N-cadherin-cytoskeletal connection leading to accelerated cardiac aging. The proposed studies will allow mechanistic insight into how the major predisposing factor in heart disease, age, affects the remodeling of N- cadherin junctions and mechanical coupling in the aging heart.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | -$73,588 | |
| Amendment | -$73,588 | |
| Amendment | -$73,588 | |
| Amendment | $73,588 | |
| Amendment | $73,588 | |
| Amendment | $73,588 | |
| Amendment | $73,588 | |
| Amendment | $4,920 | |
| Amendment | $4,920 | |
| Amendment | $241,080 | |
| Amendment | $241,080 | |
| Original award | $205,000 |
Show all 15
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Rhode Island Hospital | $9,333 |
Quick answers
Who received award R21AG077036?
R21AG077036 was awarded to Lankenau Institute For Medical Research by National Institute on Aging (National Institutes of Health) on June 15, 2024.
How much is award R21AG077036 worth?
$770,588 has been obligated on R21AG077036.
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