Project Grant R21AA026573

This federal Project Grant award, titled "MAINTENANCE RTMS FOR DEPRESSION (MAITR-DE)", is funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The $968,769 award will support a multi-site study to investigate the efficacy of maintenance repetitive transcranial magnetic stimulation (rTMS) in sustaining treatment response for individuals with treatment-resistant depression. The study will be conducted by the University of...

Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) awarded $551,464 to the Palo Alto Veterans Institute for Research on September 20, 2025, to conduct a mechanistic research study examining the efficacy of deep transcranial magnetic stimulation (DTMS) as a neuromodulation intervention for alcohol use disorder (AUD). The research will deliver a randomized, double-blind, sham-controlled clinical trial...

Federal Grant Award Summary Research Triangle Institute (RTI International) received a $901,666 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), effective September 20, 2025, with completion targeted for June 30, 2030. The project aims to develop small molecule negative allosteric modulators (NAMs) of the RXFP3 receptor as novel pharmacological treatments for alcohol use disorder (AUD). RTI will optimize...

Cooperative Agreement Summary Lovelace Biomedical Research Institute received a $1.79 million Cooperative Agreement from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research applying neuromodulation techniques to enhance the efficacy of motivational interviewing (MI) for substance use disorder (SUD) treatment. The award, obligated on September 30, 2025, with a completion date of August 31, 2027, supports investigation of...

Federal Project Grant Award Summary Spark Biomedical Inc. received a $305,545 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), effective September 1, 2025, through August 31, 2026. The award funds a research initiative investigating transcutaneous auricular neurostimulation (TAN) as a therapeutic intervention for alcohol use disorder (AUD) and alcohol withdrawal syndrome (AWS). TAN is a non-invasive...

Federal Project Grant Award Summary Real Recovery VR, Inc. received a $928,356 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), effective September 15, 2025, with completion targeted for August 31, 2026. The award funds development of a Virtual Reality (VR) platform designed for use by counselors treating patients with Alcohol Use Disorder (AUD). The platform aims to enhance evidence-based counseling...

This Project Grant from the National Institutes of Health National Institute on Drug Abuse will fund Neurobehavioral Research Inc. to provide network synchrony neurofeedback training and evaluation for opioid dependent individuals receiving medication assisted treatment. The $807,960 award, issued on September 30, 2021, will support 12 neurofeedback sessions over 8 weeks to train participants' brains to mimic adaptive changes in resting state brain network synchrony seen with long-term...

The National Institute of Mental Health (NIMH) awarded a $156,500 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Emory University to identify patients with true treatment failure for major depressive disorder (MDD) who may benefit from earlier referral to alternative treatments like transcranial magnetic stimulation, ketamine, and vagus nerve stimulation. The project aims to use trajectory classification methods to empirically separate partial response from true...

Federal Project Grant Award Summary Brown University received a $394,604 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to develop and implement a virtual reality (VR) intervention tool designed to enhance coping skills training for adults with alcohol use disorder (AUD). The project, which commenced September 25, 2025 and concludes August 31, 2028, addresses a critical treatment gap by creating...

Federal Project Grant Award Summary RTI International (Research Triangle Institute) received a $559,180 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), effective September 1, 2025, through June 30, 2030. The research initiative delivers multi-omic data integration and translational analysis services to identify neurobiological factors underlying alcohol use disorder (AUD) with and without comorbid cigarette...