Project Grant R16GM166825
- This Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), provides $503,000 to Harvey Mudd College to enhance understanding of extracellular vesicle biogenesis through substrate-associated signals. The research will interrogate factors influencing extracellular vesicle formation and selective cargo packaging in astrocytes. Engineered hydrogel substrates engaging integrins expressed by...
- The National Science Foundation (NSF) Office of Integrative Activities awarded a $738,400 Project Grant to the Morehouse School of Medicine (MSM) to investigate the synergistic effects of engineered extracellular vesicles (EVs) from stem cells and macrophages on angiogenesis, the formation of new blood vessels. The 4-year project will explore how EVs from different cell types cooperatively regulate normal and pathological angiogenesis, as well as develop novel EV-based therapeutic strategies....
- The National Institute of General Medical Sciences, under the Department of Health and Human Services National Institutes of Health, awarded the University of Delaware $392,495 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms of extracellular vesicle biogenesis and uptake. The research examines how cells release distinct extracellular vesicle subpopulations and how those vesicles mediate intercellular transport of bioactive...
- The National Institute of General Medical Sciences awarded $451,000 to The University of Texas MD Anderson Cancer Center on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to dissect the role of extracellular vesicles and matrix in wound healing. The research identifies mechanisms by which fibroblasts respond to tissue injury through extracellular vesicle cargo packaging and extracellular matrix remodeling. The project uses genetically engineered...
- The National Institute of General Medical Sciences awarded the University of Houston System $431,750 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an integrated nanophotonic imaging and spectroscopy technology for scalable, purification-free single exosome analysis. The research addresses limitations in current exosome analysis methods by developing a nanophotonic chip that combines three complementary nanoplasmonic techniques—localized...
- The National Institute of General Medical Sciences awarded the Seattle Institute For Biomedical And Clinical Research $374,550 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular regulation of endothelial glycocalyx-mediated transcytosis. The work characterizes molecular components that regulate transendothelial transport of chemokines and viral proteins across endothelial cell barriers, with emphasis on tissue-specific and...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded The Johns Hopkins University $420,936 for a Project Grant (CFDA 93.859, Biomedical Research and Research Training) on April 1, 2026. The award funds research investigating mechanisms of protein self-assembly coupled to membrane mechanics in clathrin-mediated endocytosis. The research addresses how cargo controls the nucleation and growth of...
- This $500,000 National Science Foundation project grant supports research to advance the biom anufacturing of extracellular vesicles through the integration of human induced pluripotent stem cell technology, genome engineering, and membrane nanofabrication. The primary recipient is Syracuse University, with Rochester Institute of Technology serving as a sub-awardee. Under the Biological Sciences program (CFDA 47.074), the grantees will work to generate a stable human iPSC line with enhanced EV...
- The National Institute of General Medical Sciences awarded The Research Foundation For The State University Of New York (Stony Brook University) $432,569 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the regulatory mechanisms of extracellular particle-mediated intercellular signaling. The research deciphers how cells release extracellular particles containing biomolecules to establish non-contact communication with neighboring or...
- The National Institute of General Medical Sciences awarded the University of Louisville $398,730 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct basic research on lipid regulation of the stem cell niche. The recipient will investigate how changes in lipid metabolism affect stem cell niche homeostasis using Drosophila melanogaster testis as a model system. The research builds on established findings that ectopic lipid accumulation in the...
The National Institute of General Medical Sciences awarded Howard University $190,291 for a Project Grant on September 1, 2026, to decode cargo sorting and selection mechanisms in mesenchymal stem cell-derived extracellular vesicles for next-generation therapeutic design. The research investigates how MSCs regulate the molecular content of extracellular vesicles, focusing on integrin-mediated signaling and its influence on cargo selection. The project employs engineered peptide-polymer scaffolds that mimic extracellular matrix environments to systematically analyze how integrin signaling affects EV cargo composition. Two specific aims guide the work: quantifying the influence of individual integrin ligands on MSC EV cargo, and elucidating the impact of combinatorial integrin ligands on MSC-EV cargo. The findings will support rational design of extracellular vesicles for targeted therapies in regenerative medicine, immunotherapy, and cancer treatment. The award period runs from September 1, 2026, through May 31, 2030, with work performed in Washington, DC. The award supports basic research under NIGMS's Biomedical Research and Research Training program (CFDA 93.859), which funds investigator-initiated research to advance understanding of biological processes and lay the foundation for advances in disease diagnosis, treatment, and prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $190.3k | 8/20/26 |