Project Grant R16GM166725
- The National Institute of General Medical Sciences awarded the University of Miami $501,165 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support structural and biophysical research on three human membrane proteins with significance to cardiovascular health, hemostasis, and inflammation. The funded research determines the structures and functional mechanisms of connexin channels, which coordinate electrical and metabolic activity in cardiac...
- The National Institute of General Medical Sciences awarded the University of South Florida $474,102 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct synthetic biology and genome engineering of polyketide natural products, develop bioactive metabolites from Antarctic marine invertebrates and deep-sea organisms, synthesize chemical analogs to modulate toxicity and enhance drug-like properties, and advance compound development initiatives...
- The National Institute of General Medical Sciences awarded Northeastern University $440,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop IMAGE-SEQ, a platform integrating high-resolution in vivo optical imaging with spatially resolved single-cell transcriptomics. The award funds three major expansions of the technology: integration with single-cell proteomics to capture protein-level signaling events and define how proliferative...
- The National Institute of General Medical Sciences awarded Florida International University $405,625 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the functional dynamics, membrane orientation, and complex organization of cytochrome P450 aromatase (CYP19) and its interactions with cytochrome P450 reductase (CPR). The research integrates classical biophysical techniques with advanced tools including synchrotron X-ray footprinting mass...
- The National Institute of General Medical Sciences awarded Southern Methodist University $399,927 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of desiccation tolerance in anhydrobiotic organisms. The research deciphers how certain animals survive near-complete absence of water by identifying and characterizing protective molecules—specifically late embryogenesis abundant (LEA) proteins and small heat shock...
- The National Institute of General Medical Sciences awarded the Seattle Institute For Biomedical And Clinical Research $374,550 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular regulation of endothelial glycocalyx-mediated transcytosis. The work characterizes molecular components that regulate transendothelial transport of chemokines and viral proteins across endothelial cell barriers, with emphasis on tissue-specific and...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Boston $425,333 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on cellular and molecular mechanisms of stem and progenitor cell development during tissue homeostasis and after injury. The research uses the Drosophila melanogaster blood system as a model to examine how multiple cell types within stem and progenitor cell niches use inflammatory...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded The Johns Hopkins University $420,936 for a Project Grant (CFDA 93.859, Biomedical Research and Research Training) on April 1, 2026. The award funds research investigating mechanisms of protein self-assembly coupled to membrane mechanics in clathrin-mediated endocytosis. The research addresses how cargo controls the nucleation and growth of...
- The National Institute of General Medical Sciences awarded Florida Institute of Technology Inc. $527,392 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop nanodiamond quantum sensing platforms for measuring redox dynamics in live cells. The Usselman Lab will engineer chemogenetic systems using D-amino acid oxidase to generate hydrogen peroxide with spatial and dose control in mammalian cells, then quantify redox dynamics using ratiometric...
- The National Institute of General Medical Sciences awarded Northeastern University $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to discover novel antimicrobial molecules from clostridial biosynthesis. The project characterizes cobalamin-dependent radical S-adenosylmethionine enzymes fused with non-ribosomal peptide synthetase adenylation domains found in clostridial genomes. The recipient will conduct biochemical characterization of these...
The National Institute of General Medical Sciences awarded Nova Southeastern University, Inc. $144,800 for a project grant (NIGMS R16GM166725) on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into how fever-range hyperthermia and disturbed blood flow disrupt arterial endothelial barriers through IRE1α-XBP1-dependent autophagy. The research combines in vitro studies using a bioreactor system to simulate physiological shear stress and thermal conditions with in vivo studies in mice to map endothelial barrier disruption across laminar and disturbed-flow regions of the vasculature. The work tests whether genetic knockdown or pharmacologic inhibition of IRE1α can restore vascular endothelial cadherin junction integrity and preserve barrier function during febrile illness. Performance takes place in Davie, Florida, with a period of performance from September 1, 2026, through August 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $144.8k | 8/28/26 |